Antral follicle count in predicting appropriate dose of gonadotropin in in vitro fertilization cycles

Abstract

Introduction

Controlled ovarian stimulation is an essential part of in vitro fertilization (IVF) cycles. The aim of this process is to permit follicular aspiration of approximately 8–10 oocytes. Individual women have different ovarian responses based on their ovarian reserves. Low doses of exogenous follicle-stimulating hormone (FSH) may lead to cancelation of an IVF cycle as a result of insufficient response, and high doses may also lead to cancelation due to the risk of ovarian hyperstimulation syndrome. Knowing the patient's ovarian response permits the use of individually tailored doses of gonadotropin, resulting in decreased occurrence of inappropriate ovarian responses.

Objective

To conduct a systematic review of antral follicle count (AFC) performance in adjusting the dose of gonadotropins to prevent inadequate responses in IVF cycles.

Method

A systematic review was conducted of studies published in the last 13 years that appraised AFC performance in adjusting the dose of gonadotropins to prevent inadequate responses in IVF cycles. The databases consulted were Medline, LILACS, SciELO and Pubmed. Search descriptors were “antral follicle count” and “ovarian hyperstimulation syndrome”.

Results

131 articles were found. Five articles published between 2000 and 2013 were selected.

Conclusion

AFC appears to perform well in adjusting the dose of exogenous gonadotropins to prevent inappropriate responses in IVF cycles.