Über biologische Wirkungen von Koordinationsverbindungen der Übergangsmetalle 5. Zum Einfluß von Dimethylsulfoxid auf die zytotoxischen, antiviralen und antitumoralen Eigenschaften von Cis-dichloro-diammin-platin (II): „Cis-Platin“

Abstract

In water or dimethyl sulfoxide solutions cis-platinum is subject of time depending solvolytic reactions leading to compounds with different biological effectivity. Whereas the inactivation of vaccinia, vesicular stomatitis and adeno virus type 5 was not changed if dimethyl sulfoxide or dimethyl formamide instead of destilled water were used as solvents, long time stored solutions of cis-platinum in dimethyl sulfoxide were tolerated by cells cultivated in vitro in 8–25 times higher concentrations in comparison with a freshly solved preparation. Their antiviral effectivity was maintained. On the other hand experiments with mice showed that simultaneously with the decrease of toxicity of an aged cis-platinum solution in DMSO also its antileukemic activity disappeared. In a 5 weeks old cis-platinum solution in destilled water antitumor activity was preserved in spite of enhanced toxicity.