Contraceptive exposure associates with urinary tract infection risk in a cohort of reproductive-age women: a case control study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-01 DOI:10.1080/13625187.2022.2156278

Claire Lo, Abin Abraham, Cosmin A Bejan, Seth A Reasoner, Mario Davidson, Loren Lipworth, David M Aronoff

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引用次数: 1

Abstract

Purpose: Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is unclear.

Materials and methods: Using data from Vanderbilt University Medical Centre's deidentified electronic health record (EHR), women ages 18-52 were randomly sampled and matched based on age and length of EHR. This case-control analysis tested for association between contraception exposure and outcome using UTI-positive (UTI+) as cases and upper respiratory infection+ (URI+) as controls.

Results: 24,563 UTI + cases (mean EHR: 64.2 months; mean age: 31.2 years) and 48,649 UTI-/URI + controls (mean EHR: 63.2 months; mean age: 31.9 years) were analysed. In the primary analysis, UTI risk was statistically significantly increased for the oral contraceptive pill (OCP; OR = 1.10 [95%CI = 1.02-1.11], p ≤ 0.05), intrauterine device (IUD; OR = 1.13 [95%CI = 1.04-1.23], p ≤ 0.05), etonogestrel implant (Nexplanon^®; OR = 1.56 [95% CI = 1.24-1.96], p ≤ 0.05), and medroxyprogesterone acetate injectable (Depo-Provera^®; OR = 2.16 [95%CI = 1.99-2.33], p ≤ 0.05) use compared to women not prescribed contraception. A secondary analysis that included any non-IUD contraception, which could serve as a proxy for sexual activity, demonstrated a small attenuation for the association between UTI and IUD (OR = 1.09 [95%CI = 0.98-1.21], p = 0.13).

Conclusion: This study notes potential for a small increase in UTIs with contraceptive use. Prospective studies are required before this information is applied in clinical settings.

Condensation: Although non-barrier contraception is commonly prescribed, the risk of urinary tract infections (UTI) with contraceptive exposure is poorly understood. This large-cohort, case-control study notes potential for a small increase in UTIs with contraceptive use.

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避孕暴露与育龄妇女尿路感染风险相关:一项病例对照研究。

目的:虽然非屏障避孕是常用的处方，但与避孕暴露尿路感染(UTI)的风险尚不清楚。材料和方法:使用范德比尔特大学医学中心的电子健康记录(EHR)的数据，随机抽取18-52岁的女性，并根据年龄和EHR的长度进行匹配。本病例-对照分析以尿路感染阳性(UTI+)病例和上呼吸道感染+ (URI+)病例为对照，检验避孕暴露与结局之间的关系。结果:尿路感染+病例24,563例(平均EHR: 64.2个月;平均年龄:31.2岁)和48,649例UTI-/URI +对照(平均EHR: 63.2个月;平均年龄:31.9岁)。在初步分析中，口服避孕药(OCP;OR = 1.10 [95%CI = 1.02-1.11]， p≤0.05)，宫内节育器(IUD;OR = 1.13 [95%CI = 1.04-1.23]， p≤0.05)，依替诺孕酮种植体(Nexplanon®;OR = 1.56 [95% CI = 1.24-1.96]， p≤0.05)，可注射醋酸甲孕酮(Depo-Provera®;OR = 2.16 [95%CI = 1.99-2.33]， p≤0.05)。另一项纳入非宫内节育器避孕的二次分析显示，UTI和宫内节育器之间的相关性略有减弱(OR = 1.09 [95%CI = 0.98-1.21]， p = 0.13)。结论:本研究注意到使用避孕药可能会导致尿路感染的小幅增加。在将这些信息应用于临床之前，需要进行前瞻性研究。冷凝:虽然非屏障避孕是常用的处方，但暴露于避孕药具的尿路感染(UTI)的风险知之甚少。这项大型队列、病例对照研究指出，使用避孕药可能会导致尿路感染的小幅增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.