Exploring the utility of current polygenic scores in capturing resilience.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2022-02-01 DOI:10.1097/YPG.0000000000000300

Brianna A Bucknor, Jaime Derringer

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引用次数: 0

Abstract

Although resilience has been identified to be moderately heritable, little is known about the genetic variants involved. While there has not yet been a robust genome-wide association study (GWAS) of resilience, existing GWAS of related phenotypes may provide a starting point for developing our understanding of the heritability of resilience. In a sample of older, US adults (N = 9480), we examined the extent to which proxy polygenic scores (PGS) explained the variance in resilience. Four of the 32 PGS assessed (subjective wellbeing, neuroticism, depressive symptoms and educational attainment) reached significance among participants with European ancestries, but with relatively small effects (= 0.002-0.09). Notably, PGSs derived from GWAS of PTSD among participants with either European or African ancestries were uncorrelated with resilience. Even aggregated across all available proxy PGSs, existing PGSs are not sufficient to inform our understanding of the genetics underlying the heritability of resilience. A large-scale GWAS of resilience is needed as it would provide greater insight into the genetic mechanisms underlying the heritability of resilience.

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探索当前多基因评分在捕捉韧性方面的效用。

虽然恢复力已被确定为适度遗传，但对涉及的遗传变异知之甚少。虽然目前还没有一个强大的复原力全基因组关联研究(GWAS)，但现有的相关表型的GWAS可能为我们了解复原力的遗传性提供了一个起点。在一个年龄较大的美国成年人样本中(N = 9480)，我们研究了代理多基因评分(PGS)在多大程度上解释了恢复力的差异。在被评估的32项PGS中，有4项(主观幸福感、神经质、抑郁症状和受教育程度)在欧洲血统的参与者中达到显著性，但影响相对较小(= 0.002-0.09)。值得注意的是，在欧洲或非洲血统的参与者中，PTSD的GWAS衍生的pgs与恢复力无关。即使将所有可用的代理pgs汇总在一起，现有的pgs也不足以让我们了解恢复力遗传能力的遗传学基础。一个大规模的复原力GWAS是必要的，因为它将提供更深入的了解复原力遗传的遗传机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.