The Effects of Acute and Chronic Sleep Deprivation on the Immune Profile in the Rat.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467215666220316104321

Alaa Fahmawi, Mohammad Khalifeh, Karem H Alzoubi, Abeer M Rababa'h

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引用次数: 4

Abstract

Background: Acute and chronic sleep deprivation present many health-related problems in modern societies, mainly concerning the immune system. Immune factors, particularly the interleukins, regulate sleep and, therefore, may be altered by sleep deprivation (SD).

Objectives: We aimed to investigate the possible effects of acute and chronic sleep deprivation on selected cytokines, including interleukins (IL-1β, IL-9, IL-17, and IL-23) and tumor necrosis factor- alpha (TNF-α).

Methods: The animals were grouped into acute sleep-deprived (SD; for 24 hours) and chronic sleep-deprived (8 hours a day for 10, 20, and 30-days). The SD was induced using the multipleplatforms model. The serum levels of cytokines were measured using commercially available ELISA.

Results: The serum levels of IL-1β were significantly reduced after acute SD, whereas they were increased after 20-days of chronic SD. The IL-9 levels were reduced after acute SD, increased after 10-days of SD, and reduced again after 30-days of SD. Conversely, the levels of IL-23 were not changed after acute SD, reduced after 10 days of SD, and increased after 30-days of SD. Levels of TNF-α were not changed after acute SD, whereas they were increased after 20 and 30- days of SD.

Conclusion: In conclusion, both acute and chronic SD distinctly disturb the immune profile, which might result in the emergence of various pathologies presented during sleep deprivation.

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急性和慢性睡眠剥夺对大鼠免疫功能的影响。

背景:急性和慢性睡眠剥夺在现代社会中呈现出许多与健康相关的问题，主要涉及免疫系统。免疫因子，特别是白细胞介素，调节睡眠，因此，可能会因睡眠不足而改变。目的:我们旨在研究急性和慢性睡眠剥夺对选定细胞因子的可能影响，包括白细胞介素(IL-1β、IL-9、IL-17和IL-23)和肿瘤坏死因子-α (TNF-α)。方法:将大鼠分为急性睡眠剥夺(SD)组;24小时)和慢性睡眠剥夺(每天8小时，持续10、20和30天)。采用多平台模型诱导SD。血清细胞因子水平采用市售ELISA法测定。结果:急性SD后血清IL-1β水平明显降低，慢性SD 20 d后血清IL-1β水平升高。急性SD后IL-9水平降低，SD后10天升高，SD后30天再次降低。相反，急性SD后IL-23水平没有变化，SD后10天降低，SD后30天升高。急性SD后TNF-α水平无变化，而SD后20、30 d TNF-α水平升高。结论:总之，急性和慢性SD均明显干扰了免疫谱，这可能导致睡眠剥夺过程中出现的各种病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.