Diagnostics of messenger ribonucleic acid (mRNA) severe acute respiratory syndrome-corona virus‑2 (SARS-CoV‑2) vaccination-associated myocarditis-A systematic review.

IF 0.4 4区医学 Q4 MEDICINE, LEGAL

Rechtsmedizin Pub Date : 2023-01-01 DOI:10.1007/s00194-022-00587-9

Jan M Federspiel, Frank Ramsthaler, Mattias Kettner, Gerhard Mall

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引用次数: 1

Abstract

Background: During the recent pandemic with the severe acute respiratory syndrome-corona virus‑2 the first messenger ribonucleic acid (mRNA) vaccines were approved. To facilitate mass vaccination, confidence of the general population in these new vaccines is mandatory, which is in turn strongly dependent on the availability of reliable data on complications.

Objective: Summary of the current knowledge on mRNA vaccination-associated myocarditis as a potentially fatal side effect.

Methods: Systematic literature review.

Results: Diagnostic algorithm for the postmortem diagnosis of mRNA vaccination-associated myocarditis.

Conclusion: Autopsy series of fatalities following mRNA SARS-CoV‑2 vaccination up to 6 weeks with subsequent sophisticated and interdisciplinary work-up are necessary to complement clinical data on vaccination-associated myocarditis, especially regarding the incidence of fatal courses.

Supplementary information: The online version of this article (10.1007/s00194-022-00587-9) includes a PDF file with supplemental clinical features.

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信使核糖核酸(mRNA)与严重急性呼吸综合征-冠状病毒2 (SARS-CoV - 2)疫苗接种相关心肌炎的诊断——系统评价

背景:在最近的严重急性呼吸综合征-冠状病毒- 2大流行期间，第一批信使核糖核酸(mRNA)疫苗获得批准。为了促进大规模疫苗接种，必须让普通民众对这些新疫苗有信心，而这又在很大程度上取决于是否能获得有关并发症的可靠数据。目的:总结mRNA疫苗相关心肌炎作为潜在致命副作用的现有知识。方法:系统文献复习。结果:mRNA疫苗相关心肌炎的尸检诊断算法。结论:有必要对mRNA SARS-CoV - 2疫苗接种后长达6周的死亡病例进行尸检，并随后进行复杂和跨学科的随访，以补充疫苗接种相关心肌炎的临床数据，特别是关于致命病程的发生率。补充信息:本文的在线版本(10.1007/s00194-022-00587-9)包括一个PDF文件，其中包含补充临床特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rechtsmedizin MEDICINE, LEGAL-

CiteScore

1.30

自引率

40.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Rechtsmedizin is an internationally recognized journal dealing with all aspects of forensic medicine. It provides information on current developments in forensic pathology, traumatology, traffic medicine, toxicology, serology, insurance medicine, psychopathology and legal medical issues. Freely submitted original papers allow the presentation of important clinical studies and serve scientific exchange. Case reports feature interesting and unique cases thus providing a platform for scientific information and critical discussion. Comprehensive reviews on a specific topical issue focus on providing evidenced based information on all aspects of the field. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.

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