{"title":"Antioxidant, Antimicrobial and Wound Healing Potential of Helicteres isora Linn. Leaf Extracts","authors":"Renuka Mahajan, Prakash Itankar","doi":"10.1016/j.dcmed.2020.09.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the antioxidant, antimicrobial and wound healing potential of <em>Helicteres isora</em> Linn. leaf extracts.</p></div><div><h3>Methods</h3><p>The petroleum ether, chloroform, acetone, ethanol and hydroalcoholic extracts of leaves were screened for phytochemicals. The 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) radical scavenging tests and reducing power assays were performed to measure antioxidant activity; disc diffusion methods were used to evaluate antimicrobial potential. Wound healing activity was evaluated by incision and excision wound rat models.</p></div><div><h3>Results</h3><p>The extracts contained mainly sterols and flavonoids. The hydroalcoholic extract showed remarkable antioxidant and antimicrobial potential and significant (<em>P</em> < 0.05) wound healing activity.</p></div><div><h3>Conclusions</h3><p>The identified activities of the hydroalcoholic extract may be attributable to its constituent phytochemicals.</p></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dcmed.2020.09.005","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digital Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589377720300549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
Abstract
Objective
To investigate the antioxidant, antimicrobial and wound healing potential of Helicteres isora Linn. leaf extracts.
Methods
The petroleum ether, chloroform, acetone, ethanol and hydroalcoholic extracts of leaves were screened for phytochemicals. The 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) radical scavenging tests and reducing power assays were performed to measure antioxidant activity; disc diffusion methods were used to evaluate antimicrobial potential. Wound healing activity was evaluated by incision and excision wound rat models.
Results
The extracts contained mainly sterols and flavonoids. The hydroalcoholic extract showed remarkable antioxidant and antimicrobial potential and significant (P < 0.05) wound healing activity.
Conclusions
The identified activities of the hydroalcoholic extract may be attributable to its constituent phytochemicals.
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