Barbiturates and alcohol consumption

F.B. Jolicoeur , D.B. Rondeau , M.J. Wayner, R.B. Mintz, A.D. Merkel
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引用次数: 4

Abstract

Studies on the effects of sodium phenobarbital on the ingestion of various sapid solutions in rats are reviewed and discussed. In the first three studies reported, the effects of phenobarbital on forced consumption of alcoholic and nonalcoholic solutions in water deprived rats were examined. The results of these studies indicated that phenobarbital can produce a taste aversion to ethanol solutions but not to nonalcoholic solutions in animals previously acclimated to these solutions. These data suggested a specific pharmacological interaction between this barbiturate and alcohol and a series of experiments on the effects of phenobarbital on voluntary alcohol consumption in rats was performed. The results of these studies indicate that chronic administration of certain doses of phenobarbital decreases preference for sweetened and nonsweetened 3% and 6% ethanol solutions but does not affect preference for non-alcoholic glucose and saccharin solutions. Similar administration of 30 mg/kg amobarbital, 80 mg/kg barbital, 2.5 mg/kg diazepam, 1.0 mg/kg methyprylon, and 10.0 mg/kg methaqualone did not alter intakes and preference for a 6% ethanol solution. The apparent specificity of phenobarbital in reducing ethanol consumption is discussed.

巴比妥类药物和酒精摄入
本文综述并讨论了苯巴比妥钠对大鼠摄取各种汁液的影响。在报告的前三项研究中,研究了苯巴比妥对缺水大鼠强制饮用酒精和非酒精溶液的影响。这些研究的结果表明,苯巴比妥可以产生对乙醇溶液的味觉厌恶,而不是对非酒精溶液的味觉厌恶。这些数据表明,这种巴比妥酸盐和酒精之间存在一种特殊的药理相互作用,并进行了一系列关于苯巴比妥对大鼠自愿饮酒影响的实验。这些研究的结果表明,长期服用一定剂量的苯巴比比可降低对甜味和非甜味3%和6%乙醇溶液的偏好,但不影响对非酒精性葡萄糖和糖精溶液的偏好。同样给药30mg /kg阿莫巴比妥、80mg /kg巴比妥、2.5 mg/kg地西泮、1.0 mg/kg甲基丙酮和10.0 mg/kg甲喹酮不会改变摄入量和对6%乙醇溶液的偏好。讨论了苯巴比妥降低乙醇消耗量的明显特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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