Effect of chronic treatment with haloperidol on serum prolactin, striatal opiate receptors and β-endorphin content in rat brain and pituitary

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90044-8

Nobumasa Kato, Kanhaiya R. Shah, Henry G. Friesen, Viktor Havlicek

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引用次数: 9

Abstract

1.
1. Rats were treated for 21 days with haloperidol (2mg/kg/day) and prolactin levels were measured serially. The increase in prolactin was obvious throughout the treatment and was even more prominent after repeated injections.
2.
2. Immunoreactive β-endorphin levels were increased in the pituitary, whereas decreased in N. accumbens in rats chronically treated with haloperidol. The opiate receptor binding in the striatum showed no change in treated rats as compared with controls.
3.
3. The present study suggests that 1) tolerance does not develop in prolactin-increasing action of haloperidol; 2) dopamine receptors have a role in the control of immunoreactive β-endorphin in some brain areas; 3) the various dopaminergic pathways in the brain respond differently to chronic treatment with haloperidol in terms of immunoreactive β-endorphin regulation.

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氟哌啶醇慢性治疗对大鼠血清催乳素、纹状体阿片受体及脑垂体β-内啡肽含量的影响

1.1. 用氟哌啶醇(2mg/kg/天)治疗大鼠21 d，连续测定催乳素水平。泌乳素在治疗过程中升高明显，反复注射后更为明显。长期服用氟哌啶醇的大鼠垂体的免疫反应性β-内啡肽水平升高，而伏隔核的免疫反应性β-内啡肽水平降低。与对照组相比，实验组大鼠纹状体中的阿片受体结合没有变化。本研究提示:1)氟哌啶醇的促泌乳素作用不产生耐受性;2)多巴胺受体在某些脑区具有控制免疫反应性β-内啡肽的作用;3)在免疫反应性β-内啡肽调节方面，脑内各种多巴胺能通路对氟哌啶醇慢性治疗的反应不同。

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Progress in neuro-psychopharmacology

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