Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species

Torsten Porwol, Wilhelm Ehleben, Verena Brand, Helmut Acker
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引用次数: 56

Abstract

NADPH oxidase isoforms with different gp91phox subunits as well as an unusual cytochrome aa3 with a heme a/a3 relationship of 9:91 are discussed as putative oxygen sensor proteins influencing gene expression and ion channel conductivity. Reactive oxygen species (ROS) are important second messengers of the oxygen sensing signal cascade determining the stability of transcription factors or the gating of ion channels. The formation of ROS by a perinuclear Fenton reaction is imaged by 1 and 2 photon confocal microscopy revealing mitochondrial and non-mitochondrial generation.

组织氧传感器的功能NADPH氧化酶异构体,一个不寻常的细胞色素aa3和活性氧
NADPH氧化酶异构体具有不同的gp91phox亚基,以及不寻常的细胞色素aa3与血红素a/a3的关系为9:91,被认为是影响基因表达和离子通道电导率的氧传感器蛋白。活性氧(ROS)是氧传感信号级联的重要第二信使,决定转录因子的稳定性或离子通道的门控。通过核周芬顿反应形成的ROS通过1和2光子共聚焦显微镜成像,显示线粒体和非线粒体的产生。
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