Distribution of Cortical Atrophy Associated with Cognitive Decline in Alzheimer's Disease: A Cross-Sectional Quantitative Structural MRI Study from PUMCH Dementia Cohort.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Chenhui Mao, Bo Hou, Jie Li, Shanshan Chu, Xinying Huang, Jie Wang, Liling Dong, Caiyan Liu, Feng Feng, Bin Peng, Jing Gao
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Abstract

Background: Quantitative measures of atrophy on structural MRI are sensitive to the neurodegeneration that occurs in AD, and the topographical pattern of atrophy could serve as a sensitive and specific biomarker.

Objective: We aimed to examine the distribution of cortical atrophy associated with cognitive decline and disease stage based on quantitative structural MRI analysis in a Chinese cohort to inform clinical diagnosis and follow-up of AD patients.

Methods: One hundred and eleven patients who were clinically diagnosed with probable AD were enrolled. All patients completed a systemic cognitive evaluation and domain-specific batteries. The severity of cognitive decline was defined by MMSE score: 1-10 severe, 11-20 moderate, and 21-30 mild. Cortical volume and thickness determined using 3D-T1 MRI data were analyzed using voxelbased morphometry and surface-based analysis supported by the DR. Brain Platform.

Results: The male:female ratio was 38:73. The average age was 70.8 ± 10.6 years. The mild: moderate: severe ratio was 48:38:25. Total grey matter volume was significantly related to cognition while the relationship between white matter volume and cognition did not reach statistical significance. The volume of the temporal-parietal-occipital cortex was most strongly associated with cognitive decline in group analysis, while the hippocampus and entorhinal area had a less significant association with cognitive decline. Volume of subcortical grey matter was also associated with cognition. Volume and thickness of temporoparietal cortexes were significantly correlated with the cognitive decline, with a left predominance observed.

Conclusion: Cognitive deterioration was associated with cortical atrophy. Volume and thickness of the left temporal-parietal-occipital cortex were most important in early diagnosis and longitudinal evaluation of AD in clinical practice. Cognitively relevant cortices were left predominant.

与阿尔茨海默病认知能力下降相关的皮质萎缩分布:来自PUMCH痴呆队列的横断面定量结构MRI研究
背景:结构MRI上萎缩的定量测量对阿尔茨海默病发生的神经退行性变很敏感,萎缩的地形模式可以作为一种敏感和特异性的生物标志物。目的:我们旨在通过定量结构MRI分析,研究与认知能力下降和疾病分期相关的皮质萎缩分布,为AD患者的临床诊断和随访提供依据。方法:入选111例临床诊断为AD的患者。所有患者都完成了系统认知评估和领域特异性电池。认知能力下降的严重程度由MMSE评分确定:1-10重度,11-20中度,21-30轻度。使用3D-T1 MRI数据确定的皮质体积和厚度,使用dr脑平台支持的基于体素的形态测量和基于表面的分析进行分析。结果:男女比例为38:73。平均年龄70.8±10.6岁。轻度:中度:重度比例为48:38:25。脑灰质总体积与认知能力显著相关,脑白质体积与认知能力的关系无统计学意义。在组分析中,颞顶枕皮质的体积与认知能力下降的相关性最强,而海马和内嗅区与认知能力下降的相关性不太显著。皮层下灰质的体积也与认知有关。颞顶皮质的体积和厚度与认知能力下降显著相关,以左侧为主。结论:认知功能减退与皮质萎缩有关。在临床实践中,左侧颞顶枕皮质的体积和厚度对阿尔茨海默病的早期诊断和纵向评价最为重要。认知相关皮层占主导地位。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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