Field efficacy and safety of Felpreva® (tigolaner, emodepside and praziquantel) spot-on for the treatment of natural ear mite infestations (Otodectes cynotis) and notoedric mange (Notoedres cati) in cats

IF 1.7 Q3 PARASITOLOGY
Katrin Blazejak , Dejan Cvejić , Klaus Hellmann , Hannah Ringeisen , Hannah Hamburg , Gabriele Petry , Tanja N. Knoppe , Norbert Mencke
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Abstract

The miticide efficacy of a single treatment with Felpreva® (tigolaner, emodepside and praziquantel) spot-on solution for cats was evaluated in two European field studies. One study was conducted in cats naturally infested with Otodectes cynotis. The other study was conducted in cats naturally infested with Notoedres cati. In both studies, the presence of viable mites was confirmed prior to treatment (Day -1/Day 0) and re-evaluated on Day 14 (O. cynotis study) and on Day 28 (both studies). Efficacy was calculated based on the number of viable mites found after treatment. In the O. cynotis study, the primary criterion was the percentage of mite-free cats after treatment with Felpreva® compared to a sarolaner/selamectin combination (Stronghold® Plus, Zoetis) as a positive control. In the N. cati study, the primary criterion was the difference between arithmetic mean mite counts of cats treated with Felpreva® and cats treated with a placebo formulation (solketal). Secondary criteria in both studies were changes in clinical lesion scores after treatment. In both studies, all Felpreva®-treated cats were mite-free (100% parasitological cure) on Day 28, 4 weeks after treatment. Signs of mange on Day 28 were clinically improved in all O. cynotis-infested cats (100%) and clinically cured in all N. cati-infested cats (100%). There were no records of any adverse events or application site reactions in Felpreva®-treated cats.

Abstract Image

Felpreva®(tigolaner, emodepside和吡喹酮)现场治疗猫自然耳螨感染(耳螨炎)和猫爪癣(猫爪癣)的有效性和安全性
在欧洲的两项实地研究中,评估了Felpreva®(替戈兰、莫地苷和吡喹酮)单次治疗猫的杀螨效果。其中一项研究是在自然感染耳检漏症的猫身上进行的。另一项研究是在猫Notoedres自然感染的猫身上进行的。在两项研究中,在治疗前(第1天/第0天)确认活螨的存在,并在第14天(cynotis研究)和第28天(两项研究)重新评估。根据治疗后发现的活螨数量计算效果。在O. cynotis研究中,主要标准是使用Felpreva®治疗后无螨虫猫的百分比,与使用sarolaner/selamectin组合(Stronghold®Plus, Zoetis)作为阳性对照相比。在猫螨研究中,主要标准是用Felpreva®治疗的猫和用安慰剂制剂(solketal)治疗的猫的算术平均螨数之间的差异。两项研究的次要标准都是治疗后临床病变评分的变化。在两项研究中,所有接受Felpreva®治疗的猫在治疗后4周的第28天均无螨虫(100%寄生虫治愈)。所有感染猫奈瑟虫病的猫在第28天的疥疮症状均有临床改善(100%),所有感染猫奈瑟虫病的猫在临床治愈(100%)。在Felpreva®治疗的猫中没有任何不良事件或应用部位反应的记录。
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CiteScore
3.60
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