Process biology: integrated genomics and bioinformatics tools for improved target assessment

Abstract

The availability of the human genome sequence has greatly increased the number of potential drug targets in recent years. As a result, the way targets are assessed has become crucial to the success of the drug discovery process. Unfortunately, the traditional methods relied on by the pharmaceutical industry to identify and validate targets are too slow and labor-intensive to be useful in the current environment. One solution to this dilemma is to adopt a new paradigm, which we call Process Biology. Process Biology integrates genomics and bioinformatics tools into automated, optimized modules that can be applied readily to a wide range of biological questions. By using organizational principles not usually applied to biological experiments, Process Biology can significantly impact target assessment and assist in decision-making throughout the drug discovery process.