{"title":"Mesoderm cell migration in the vertebrate gastrula","authors":"Rudolf Winklbauer","doi":"10.1006/sedb.1994.1013","DOIUrl":null,"url":null,"abstract":"<div><p>Mesoderm migration across the inner surface of the outer embryonic layer is an essential morphogenetic mechanism in vertebrate gastrulation. Conserved traits of this process are (1) cadherin-dependent cohesion of the mesoderm, and (2) a predominant role for fibronectin in mediating mesoderm cell-substrate interactions. Compared to lower vertebrates, differentiation of the outer substrate-forming cell layer is accelerated in amniotes, providing mesoderm cells with a basement membrane substrate instead of a loose network of extracellular matrix fibrils. Guidance cues which determine the direction of mesoderm migration have been demonstrated in the fibrillar matrix of the amphibian gastrula.</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"5 2","pages":"Pages 91-99"},"PeriodicalIF":0.0000,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/sedb.1994.1013","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044578184710139","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Mesoderm migration across the inner surface of the outer embryonic layer is an essential morphogenetic mechanism in vertebrate gastrulation. Conserved traits of this process are (1) cadherin-dependent cohesion of the mesoderm, and (2) a predominant role for fibronectin in mediating mesoderm cell-substrate interactions. Compared to lower vertebrates, differentiation of the outer substrate-forming cell layer is accelerated in amniotes, providing mesoderm cells with a basement membrane substrate instead of a loose network of extracellular matrix fibrils. Guidance cues which determine the direction of mesoderm migration have been demonstrated in the fibrillar matrix of the amphibian gastrula.