In search of an ideal analgesic for common acute pain

Nicholas D. Moore
{"title":"In search of an ideal analgesic for common acute pain","authors":"Nicholas D. Moore","doi":"10.1016/j.acpain.2009.09.003","DOIUrl":null,"url":null,"abstract":"<div><p><span>The choice of an oral analgesic is an important determinant in achieving effective pain relief. Properties of an ‘ideal analgesic’ required for the management of acute pain are discussed and current evidence for the suitability of available analgesics – </span>acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen), opioids and combination therapy – is reviewed. The hypothesis that an ‘ideal analgesic’ for acute pain should have a rapid onset of action, act over an extended period of time, reduce awareness of pain quickly and minimise interruption by pain, be well tolerated and produce analgesia over a wide range of pain types in different patient populations, is proposed herein. Currently available analgesics may fulfil only some of these characteristics and, because individual patient response also varies, the challenge is to define what constitutes an acceptable analgesic for a specific patient or pain type.</p><p>Various tools for measurement of each of these characteristics exist, but there is currently no single measure to determine the ‘ideal analgesic’ for a specific patient with a specific pain type that takes into account all the characteristics of an ‘ideal analgesic’ and provides an overall measure to quantify the quality of relief produced.</p></div>","PeriodicalId":100023,"journal":{"name":"Acute Pain","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.acpain.2009.09.003","citationCount":"34","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acute Pain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1366007109000473","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 34

Abstract

The choice of an oral analgesic is an important determinant in achieving effective pain relief. Properties of an ‘ideal analgesic’ required for the management of acute pain are discussed and current evidence for the suitability of available analgesics – acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen), opioids and combination therapy – is reviewed. The hypothesis that an ‘ideal analgesic’ for acute pain should have a rapid onset of action, act over an extended period of time, reduce awareness of pain quickly and minimise interruption by pain, be well tolerated and produce analgesia over a wide range of pain types in different patient populations, is proposed herein. Currently available analgesics may fulfil only some of these characteristics and, because individual patient response also varies, the challenge is to define what constitutes an acceptable analgesic for a specific patient or pain type.

Various tools for measurement of each of these characteristics exist, but there is currently no single measure to determine the ‘ideal analgesic’ for a specific patient with a specific pain type that takes into account all the characteristics of an ‘ideal analgesic’ and provides an overall measure to quantify the quality of relief produced.

寻找一种理想的止痛剂治疗常见的急性疼痛
口服镇痛药的选择是实现有效缓解疼痛的重要决定因素。讨论了治疗急性疼痛所需的“理想镇痛药”的特性,并回顾了现有镇痛药——对乙酰氨基酚、非甾体抗炎药(NSAIDs)(如布洛芬)、阿片类药物和联合治疗——适用性的现有证据。本文提出了一种假设,即急性疼痛的“理想镇痛药”应该具有快速起效,在较长的时间内起作用,快速降低疼痛意识,最大限度地减少疼痛的中断,耐受性良好,并在不同患者群体的广泛疼痛类型中产生镇痛。目前可用的镇痛药可能只满足其中的一些特征,而且由于个体患者的反应也各不相同,因此对特定患者或疼痛类型定义可接受的镇痛药是一项挑战。存在各种测量这些特征的工具,但目前没有单一的测量方法来确定具有特定疼痛类型的特定患者的“理想镇痛药”,考虑到“理想镇痛药”的所有特征,并提供量化所产生的缓解质量的总体测量方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信