Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects.

IF 2.1 Q3 NEUROSCIENCES

Current Behavioral Neuroscience Reports Pub Date : 2022-12-01 Epub Date: 2022-09-27 DOI:10.1007/s40473-022-00251-2

Elise E DeVito, Mehmet Sofuoglu

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引用次数: 0

Abstract

Purpose of review: This article reviews recent research on how catechol-O-methyltransferase (COMT) may impact cigarette smoking behavior, and how effects may be sex-sensitive. Preliminary data are presented on sex-sensitive effects of COMT on response to short-term abstinence in individuals who smoke.

Recent findings: Although research is mixed, functional variants in the COMT gene have been linked with smoking behavior, cessation outcomes and nicotine abstinence-related symptoms. Our proof-of-concept preliminary data from a human laboratory study of individuals who smoke cigarettes found that those with the high COMT enzyme activity genotype (Val/Val) reported more severe smoking urges and withdrawal symptoms following overnight abstinence than Met carriers. These effects were present in women, but not in men and were abstinent-dependent, in that they dissipated following nicotine administration.

Summary: The preliminary data showing sex-sensitive pharmacogenetic effects may shed light on mechanisms contributing to sex differences in barriers to smoking cessation or potential sex-specific treatment options.

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儿茶酚- o -甲基转移酶对吸烟的影响:性别敏感效应概念的回顾和证明。

综述目的:本文综述了最近关于儿茶酚- o -甲基转移酶(COMT)如何影响吸烟行为的研究，以及这种影响可能是性别敏感的。初步数据提出了性别敏感效应的COMT对反应短期戒烟的个人谁吸烟。最新发现:尽管研究结果不一，但COMT基因的功能变异与吸烟行为、戒烟结果和尼古丁戒断相关症状有关。我们从吸烟个体的人体实验室研究中获得的概念验证初步数据发现，那些具有高COMT酶活性基因型(Val/Val)的人在一夜戒烟后报告的吸烟冲动和戒断症状比Met携带者更严重。这些影响在女性中存在，但在男性中没有，并且是依赖于戒烟的，因为它们在服用尼古丁后会消失。摘要:显示性别敏感的药理学效应的初步数据可能揭示导致戒烟障碍的性别差异的机制或潜在的性别特异性治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Behavioral Neuroscience Reports Medicine-Public Health, Environmental and Occupational Health

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Under the leadership of Emil Coccaro, Current Behavioral Neuroscience Reports will provide an in-depth review of topics covering personality and impulse control disorders, psychosis, mood and anxiety disorders, genetics and neuroscience, geropsychiatry and cognitive disorders of late life, child and developmental psychiatry, addictions, and neuromodulation.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of behavioral neuroscience.