Cancer du sein et diabète de type 2 : des interactions complexes

Gynecologie Obstetrique & Fertilite Pub Date : 2016-12-01 DOI:10.1016/j.gyobfe.2016.09.004

L. Bernard , N. Reix , J.-C. Benabu , V. Gabriele , C. Mathelin

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引用次数: 4

Abstract

The aim of this literature review was to quantify the incidence and mortality of breast cancer for women treated for a diabetes mellitus and to analyze the complex relationship between these two common diseases.

Methods

The articles analyzed were extracted from the PubMed database from 2000 to 2015. A total of 22 case/control studies or cohorts were retained, allowing the realization of a meta-analysis.

Results

The incidence of breast cancer for women with diabetes is significantly increased for cohorts (RR = 1.32; 95% CI: 1.06 to 1.65) and not significantly for case/control studies (RR = 1.46; 95% CI: 0.99 to 2.26). Overall, mortality of women with breast cancer is significantly increased for diabetic patients compared with non-diabetic patients (RR = 1.53; 95% CI: 1.23 to 1.90). The links between diabetes and breast cancer are explained by common risk factors (overweight/obesity, qualitative and quantitative dietary errors, physical inactivity), biological changes and the impact of some anti-diabetic treatments or hormonotherapy.

Conclusion

Physicians facing a diabetic patient treated for breast cancer have a role in choosing the best anti-diabetic treatment and implementing lifestyle modifications. Diabetic women without breast cancer should participate in organized breast screening programs and have an annual breast clinical examination.

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乳腺癌和2型糖尿病:复杂的相互作用

本文献综述的目的是量化接受糖尿病治疗的女性乳腺癌的发病率和死亡率，并分析这两种常见疾病之间的复杂关系。方法选取2000 - 2015年PubMed数据库中的文章进行分析。总共保留了22个病例/对照研究或队列，从而实现了荟萃分析。结果两组糖尿病女性乳腺癌发病率显著增高(RR = 1.32;95% CI: 1.06 ~ 1.65)，病例/对照研究无显著性差异(RR = 1.46;95% CI: 0.99 ~ 2.26)。总体而言，与非糖尿病患者相比，糖尿病患者患乳腺癌的女性死亡率显著增加(RR = 1.53;95% CI: 1.23 ~ 1.90)。糖尿病和乳腺癌之间的联系可以通过常见的风险因素(超重/肥胖、定性和定量饮食错误、缺乏体育活动)、生物学变化以及一些抗糖尿病治疗或激素治疗的影响来解释。结论面对治疗乳腺癌的糖尿病患者，医师应在选择最佳的抗糖尿病治疗方案和实施生活方式改变方面发挥作用。无乳腺癌的糖尿病妇女应参加有组织的乳房筛查项目，每年进行一次乳房临床检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologie Obstetrique & Fertilite 医学-妇产科学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

4-8 weeks