Trends in Diabetes Medication Taking and Incidence of Depression in Patients with Type 2 Diabetes: A Retrospective Cohort Study from 2010 to 2018.

IF 2 3区心理学 Q3 PSYCHOLOGY, CLINICAL

International Journal of Behavioral Medicine Pub Date : 2024-04-01 Epub Date: 2023-03-23 DOI:10.1007/s12529-023-10172-3

Lin-Na Chou, Mukaila A Raji, Xiaoying Yu, Yong-Fang Kuo

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引用次数: 0

Abstract

Background: This study examined the trends in diabetes medication taking and its association with the incidence of depression in patients with type 2 diabetes (T2D).

Method: A retrospective cohort of Medicare enrollees with regular care in 2010 was defined from 100% Texas Medicare claims. The impact of medication taking on incident depression was evaluated from 2010 to 2018. Cox proportional hazards regressions were used to estimate the association between medication taking and depression.

Results: A total of 72,461 patients with T2D and with regular care were analyzed. Among 60,216 treated patients, the regular medication taking rate slightly increased from 60.8 to 63.2% during the study period. Patients with regular medication taking at baseline had a 9% lower risk of developing depression (hazard ratio [HR]: 0.91, 95% confidence interval [CI]: 0.89-0.94), and the magnitude of the association increased after adjustment of the model for time-varied medication taking (HR: 0.82, 95% CI: 0.79-0.85). The presence of nephropathy had the greatest mediating effect (23.2%) on the association of medication taking and depression.

Conclusion: We demonstrated a steady but modest increase in regular diabetes medication taking over a 9-year period and a significant relationship between medication taking and incident depression in patients with T2D.

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2 型糖尿病患者的糖尿病药物服用趋势和抑郁症发病率：2010年至2018年回顾性队列研究》。

研究背景本研究探讨了 2 型糖尿病（T2D）患者服用糖尿病药物的趋势及其与抑郁症发病率的关系：方法：从 100% 的德克萨斯州医疗保险报销单中定义了 2010 年定期接受治疗的医疗保险参保者的回顾性队列。从 2010 年到 2018 年，评估了服药对抑郁症事件的影响。采用 Cox 比例危险度回归估算服药与抑郁之间的关联：共分析了72461名接受常规治疗的T2D患者。在60216名接受治疗的患者中，定期服药率在研究期间从60.8%略增至63.2%。基线定期服药的患者罹患抑郁症的风险降低了 9%（危险比 [HR]：0.91，95% 置信区间 [CI]：0.89-0.94），在根据服药时间变化调整模型后，这种关联的程度有所提高（HR：0.82，95% 置信区间 [CI]：0.79-0.85）。肾病的存在对服药与抑郁之间的关联具有最大的中介效应（23.2%）：我们的研究表明，在 9 年的时间里，糖尿病患者定期服药的人数稳步但适度增加，服药与 T2D 患者抑郁事件之间存在显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Behavioral Medicine PSYCHOLOGY, CLINICAL-

CiteScore

5.20

自引率

3.70%

发文量

期刊介绍： The International Journal of Behavioral Medicine (IJBM) is the official scientific journal of the International Society for Behavioral Medicine (ISBM). IJBM seeks to present the best theoretically-driven, evidence-based work in the field of behavioral medicine from around the globe. IJBM embraces multiple theoretical perspectives, research methodologies, groups of interest, and levels of analysis. The journal is interested in research across the broad spectrum of behavioral medicine, including health-behavior relationships, the prevention of illness and the promotion of health, the effects of illness on the self and others, the effectiveness of novel interventions, identification of biobehavioral mechanisms, and the influence of social factors on health. We welcome experimental, non-experimental, quantitative, qualitative, and mixed-methods studies as well as implementation and dissemination research, integrative reviews, and meta-analyses.