Métabolisme protéique et insuffisance rénale chronique

Abstract

Protein metabolism is modified in the course of chronic renal failure, whatever its stage or the type of renal replacement therapy, haemodialysis, peritoneal dialysis or renal transplantation. Protein catabolism results, rather than chronic renal failure per se, from associated conditions such as chronic inflammation, metabolic acidosis and peripheral resistance to insulin. Nutritional parameters reflecting body-protein stores are frequently altered in patients with chronic renal failure, with deleterious consequences on morbidity and mortality. Correction of these different abnormalities may maintain nutritional status and improve the outcome of patients with chronic renal failure.