Statistical Optimization of Lactic Acid Extraction Using Green Solvent and Mixed Extractants (TOA and TOMAC)

Chemical Engineering Research Bulletin Pub Date : 2020-06-04 DOI:10.3329/cerb.v21i1.47369

Anil Kumar, Avinash Thakur

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引用次数: 3

Abstract

Since some previous years, reactive extraction has become more attractive and competitive technique for the separation and purification of lower carboxylic acids from fermentation broth as well as from dilute aqueous streams. This paper shows the results of investigation of reactive extraction of lactic acid (LA) from an aqueous solution using the synergistic mixture of the extractants (TOA (tri-n-octylamine) and TOMAC (Tri-n-octylmethylammonium chloride)) and a non-toxic and biocompatible green solvent (soybean oil). Three-level Box-Behnken design (BBD) under response surface methodology (RSM) was opted for the experimental design and to interpret the mutual effect of seven independent process parameters on the LA distribution coefficient (KD). The maximum values of LA distribution coefficient (KD=2.51) and its extraction efficiency (ηη=71.5%) were obtained for the optimum values of various process parameters such as 0.02 [M] initial LA concentration (CC1), 0.5 (v/v) extractant ratio (α), 28.66% (v/v) mixed extractants concentration (ψ), 2 (v/v) phase ratio (φ), 270C temperature (T), 102 rpm stirring speed (ω), and 63 mincontact time (τ). This present investigation will provide a noble discussion on LA reactive extraction using green solvent and on various influencing process parameters for gaining the enhanced value of LA distribution coefficient (KD). Chemical Engineering Research Bulletin 21(2019) 20-35

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绿色溶剂和混合萃取剂(TOA和TOMAC)萃取乳酸的统计优化

近年来，反应萃取法已成为从发酵液和稀水中分离和纯化低羧酸的一种极具吸引力和竞争力的技术。本文介绍了三正辛胺(TOA)和三正辛基甲基氯化铵(TOMAC)两种萃取剂与无毒、生物相容性好的绿色溶剂(大豆油)协同萃取水溶液中乳酸(LA)的研究结果。采用响应面法(RSM)下的三水平Box-Behnken设计(BBD)进行试验设计，以解释7个独立工艺参数对LA分布系数(KD)的相互影响。在初始LA浓度为0.02 [M] (CC1)、萃取剂比为0.5 (v/v)、混合萃取剂浓度为28.66% (v/v) (ψ)、相比为2 (v/v) (φ)、温度为270℃(T)、搅拌转速为102 rpm (ω)、接触时间为63 min (τ)的条件下，得到了萃取剂分配系数最大值(KD=2.51)和萃取效率ηη=71.5%。本研究将对绿色溶剂反应萃取LA及影响LA分配系数(KD)提高值的各种工艺参数进行讨论。化工研究通报21(2019)20-35

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Chemical Engineering Research Bulletin

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