Combination Effect of Cefmenoxime with Four Aminoglycosides on Enterobacteriaceae Susceptible and Moderately Susceptible to this New Cephalosporin

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... Pub Date : 1984-08-01 DOI:10.1016/S0174-3031(84)80064-5

M.O. Husson , D. Izard, A. Bryskier, P. Vincent, H. Leclerc

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引用次数: 1

Abstract

The inhibitory combination effect of cefmenoxime with gentamicin, tobramycin, netilmicin and amikacin against 148 Enterobacteriaceae was compared using the checkerboard agar dilution technique. On average 41% of cefmenoxime-moderately susceptible (MIC between 2 and 32 μg/ml) or cefmenoxime-resistant (MIC > 32 μg/ml) strains were inhibited by synergistic, and 23,5% by partial synergistic cefmenoxime-aminoglycosides combinations. Against cefmenoxime-susceptible strains, these rates of synergy or partial synergy were twofold lower, but only one isolate was not susceptible to these combinations. The amikacin-cefmenoxime interaction was the most performant.

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头孢美肟与四种氨基糖苷类药物联合应用对该新型头孢菌素敏感和中敏感肠杆菌的影响

采用棋盘琼脂稀释法比较头孢美肟与庆大霉素、妥布霉素、奈替米星和阿米卡星联合抑菌效果。平均41%的头孢甲肟中度敏感(MIC在2 ~ 32 μg/ml之间)或耐药(MIC >头孢美肟-氨基糖苷部分增效联合对菌株的抑制作用为23.5%，增效联合对菌株的抑制作用为32 μg/ml。对于头孢莫肟敏感菌株，这些协同或部分协同率低两倍，但只有一个分离株对这些联合不敏感。阿米卡辛-头孢美肟相互作用效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...

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