A review of transthyretin cardiac amyloidosis.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Nikita Jhawar, Juan Carlos Leoni Moreno, Razvan Chirila
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引用次数: 0

Abstract

Transthyretin cardiac amyloidosis is a progressive disease known to cause heart failure, conduction anomalies, and arrythmias. Due to poor outcomes and mortality from severe cardiomyopathy, prevalence and incident rates are often underreported. As global longevity is increasing and rates of amyloidosis are also increasing, there is a need to improve diagnostic and therapeutic interventions. Previously, symptom management and transplantation were the mainstay of treatment for heart failure symptoms, but studies using RNAi and siRNA technologies have shifted the paradigm of therapeutic strategy in amyloid cardiomyopathy management. Additionally, early detection and clinical monitoring with numerous imaging and non-imaging techniques are being increasingly investigated. Here, we review the epidemiology, pathophysiology, diagnosis, and management of transthyretin amyloid cardiomyopathy.

转甲状腺素型心脏淀粉样变性的研究进展。
转甲状腺素型心脏淀粉样变性是一种进行性疾病,已知可导致心力衰竭、传导异常和心律失常。由于严重心肌病的预后和死亡率较差,患病率和发生率往往被低估。随着全球寿命的增加和淀粉样变的发病率也在增加,有必要改进诊断和治疗干预措施。以前,症状管理和移植是治疗心力衰竭症状的主要方法,但使用RNAi和siRNA技术的研究已经改变了淀粉样心肌病治疗策略的范例。此外,许多影像学和非影像学技术的早期检测和临床监测正在得到越来越多的研究。在这里,我们回顾流行病学,病理生理,诊断和治疗甲状腺素淀粉样心肌病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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