Review on applications of Pullulan in bone tissue engineering: Blends and composites with natural and synthetic polymers

M. Manivannan, S. S. Nathan, P. Sasikumar, L. Ramkumar, D. Navaneethan, P. Prabu, F. M. Anjalin, N. Dharamarj, M. Alqahtani, Mohamed Abbas
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引用次数: 1

Abstract

Pullulan (PUL) has a diverse range of applicationsdue to its many therapeutic benefits, including biodegradability, biocompatibility, nontoxicity, antimicrobial activity, and adsorption. They are combined with chitosan, polyvinyl pyrrolidone (PVP), polycaprolactone (PCL), heparin, fluorescent polystyrene nanoparticles (PS-NPs), and carboxyl Pullulan to develop properties such as thermal stability, mechanical properties, pH resistance, chemical stability, toughness. The effects of Pullulan content on the properties of the solution, as well as the morphology of the resultant nanofibers, were investigated >80%. The concept of a scaffold can be a useful notion to improve the mechanical behavior of hydrogel-based scaffolds. Compositional analysis by Differential scanning calorimetry (DSC) revealed that Pullulan might enhance the mechanical properties of the nanofibers. This review focuses on the combination and analysis of Pullulan blends and composites of natural and synthetic polymers, as well as their capability in biomedical fields and bone tissue engineering, for example in drug delivery, insulin delivery, food industry, medicinal and biomedical applications, antimicrobial wound dressings, cancer cell targeting, anticancer vaccine improvement, new biopolymer development, food product development and sensing. The electro spinning procedure and the materials employed in it will be covered in this review. The use of Pullulan electrospun nanofibers structures in tissue engineering will also be covered in this paper. The benefits, restrictions, and future opinions were studied. This is because of Pullulan-based polymers have a variety of properties.
普鲁兰在骨组织工程中的应用综述:与天然聚合物和合成聚合物共混物及复合材料
pululan (PUL)由于其生物可降解性、生物相容性、无毒性、抗菌活性和吸附性等诸多治疗益处而被广泛应用。它们与壳聚糖、聚乙烯醇吡啶酮(PVP)、聚己内酯(PCL)、肝素、荧光聚苯乙烯纳米颗粒(PS-NPs)和羧基普鲁兰结合,形成热稳定性、机械性能、耐pH、化学稳定性、韧性等性能。普鲁兰含量对溶液性能和纳米纤维形貌的影响大于80%。支架的概念可以是一个有用的概念,以改善水凝胶基支架的力学性能。差示扫描量热法(DSC)的成分分析表明,普鲁兰可以增强纳米纤维的力学性能。本文综述了天然聚合物和合成聚合物普鲁兰共混物和复合材料的组合和分析,以及它们在生物医学和骨组织工程领域的应用,如药物输送、胰岛素输送、食品工业、医药和生物医学应用、抗菌伤口敷料、癌细胞靶向、抗癌疫苗改进、新型生物聚合物开发、食品产品开发和传感等。本文将介绍电纺丝工艺及其所用材料。本文还将介绍普鲁兰静电纺纳米纤维结构在组织工程中的应用。研究了收益、限制和未来的意见。这是因为普鲁兰基聚合物具有多种性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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