To Compare the Side Effect of Dexmedetomidine and Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Total Abdominal Hysterectomy

Abstract

Background: Addition of adjuvants to routinely used intrathecal drugs is cornerstone in safe and effective prolongation of single shot spinal block for gynecological surgery. In resource deficient countries, where epidural anaesthesia is usually not used because of cost factor, adjuvants are routinely used to prolong the effect of regional anaesthesia. Alpha 2 agonists are considered best drugs as adjuvants, but there is inconclusive data in literature about the block characteristic, dose at which to be used and side effect after use of these drugs. Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. Results: Hypotension was seen in 5 patients of Group C and 4 patients of Group D. Three patients in both the groups required 2 doses of Inj mephenteramine and 2 patients in Group C and 1 in Group D required single dose of Vasopressor (Inj mephentermine). (p=0.83). Five patients had bradycardia, 3 Nausea and 3 had shivering in Group C, while only 2 patients had side effects in Group D i.e one patient had bradycardia and another nausea, vomiting. (p= 0.657) Conclusion: We observed hypotension, bradycardia, nausea vomiting and post operative shivering in our patients during the study period but there was no statistical significance achieved amongst the groups. (p>0.05).