The science behind the relations among cancer, height, growth patterns, and growth hormone axis.

IF 4.1 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Endocrine-related cancer Pub Date : 2023-03-10 Print Date: 2023-04-01 DOI:10.1530/ERC-22-0400
Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, Wouter W de Herder
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引用次数: 1

Abstract

The association between growth hormone (GH) and carcinogenesis has long been postulated. The rationale for this association is that several components of the GH axis play an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis and have been tested as targets for cancer therapy. Epidemiological and clinical studies have examined the association between height, growth patterns, and insulin-like growth factor 1 (IGF1) levels with the most common types of malignancies, while genome-wide association studies have revealed several height-associated genes linked to cancer and/or metastasis-driving pathways. In this context, a permissive role of the GH-IGF signaling system in the link between height and cancer risk has also been investigated. In animal and human models, genetic defects associated with GH deficiency or resistance are associated with protection from tumor development, while the risk of malignancies in acromegaly or in patients exposed to recombinant GH therapy has long been a matter of concern and scrutiny. In this review, we present a narrative and historical review covering the potential relations among height, growth patterns, GH axis, and cancer.

癌症、身高、生长模式和生长激素轴之间关系背后的科学。
生长激素(GH)与致癌作用之间的联系早已被假定。这种关联的基本原理是GH轴的几个成分在细胞增殖、分化、凋亡和血管生成的调节中起着重要作用,并已被测试为癌症治疗的靶点。流行病学和临床研究已经检查了身高、生长模式和胰岛素样生长因子1(IGF1)水平与最常见的恶性肿瘤类型之间的关联,而全基因组关联研究已经揭示了与癌症和/或转移驱动的生活途径相关的几个身高相关基因。在这种情况下,GH-IGF信号系统在身高和癌症风险之间的联系中的许可作用也已被研究。在动物和人类模型中,与生长激素缺乏或耐药性相关的基因缺陷与防止肿瘤发展有关,而肢端肥大症或接受重组生长激素治疗的患者患恶性肿瘤的风险长期以来一直是人们关注和仔细研究的问题。在这篇综述中,我们对身高、生长模式、生长激素轴和癌症之间的潜在关系进行了叙述和历史回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine-related cancer
Endocrine-related cancer 医学-内分泌学与代谢
CiteScore
7.80
自引率
2.60%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Endocrine-Related Cancer is an official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, the United Kingdom and Ireland Neuroendocrine Society, and the Japanese Hormones and Cancer Society. Endocrine-Related Cancer provides a unique international forum for the publication of high quality original articles describing novel, cutting edge basic laboratory, translational and clinical investigations of human health and disease focusing on endocrine neoplasias and hormone-dependent cancers; and for the publication of authoritative review articles in these topics. Endocrine neoplasias include adrenal cortex, breast, multiple endocrine neoplasia, neuroendocrine tumours, ovary, prostate, paraganglioma, parathyroid, pheochromocytoma pituitary, testes, thyroid and hormone-dependent cancers. Neoplasias affecting metabolism and energy production such as bladder, bone, kidney, lung, and head and neck, are also considered.
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