Comparative Double Blind Clinical Trial Study of Side Effects of Areca catechu L., TTHF, and Mebendazole, in Treatment of Human Mixed Worm Infection

Advances in Natural Science Pub Date : 2012-06-26 DOI:10.3968/J.ANS.1715787020120502.1846

Buavaroon Srichaikul, Weerasak Seubsoh, S. Samappito, Gordon Bakker

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Abstract

This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was carried on with 200 samples with randomized control trial clinical study in order to examine the side effects of Areca catechu Linn., TTHF and Mebendazole after the treatment of antihelmintic activity of mixed worms infection in human . The 3 experimental groups consisted of 50 patients in each group and 50 patients for control group testing with placebo with inclusion and exclusion criteria which were screened by parasitologist of mixed worm infection symptoms samples. The investigation of side effects were investigated after treating the first dose of Areca catechu Linn, TTHF and Mebendazole which were confirmed by the physician and the pharmacist. The side effects data were collected before and after the treatment with Areca catechu Linn. and with placebo. The result showed that Areca catechu Linn. had 20% of diarrhea and 20% of nausea, 20% of diarrhea in Mebendazole and 0% in TTHF. The suggestion of this study should increase the number of samples of worm infected patients and also the numbers of locations in Thailand in order to obtain various kinds of helminthes. Key words: TTHF (Thai Traditional Herbal Formula); Mebendazole; Areca catechu Linn.; Side effects; Antihelmintic activity

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儿茶槟榔、四氢呋喃、甲苯达唑治疗人混合性蠕虫感染副反应的双盲对照临床研究

这项研究是在泰国东北部玛哈萨拉卡姆省玛哈萨拉卡姆初级保健中心进行的。为探讨槟榔的副作用，采用随机对照试验临床研究方法，对200个样品进行了试验。四氢呋喃四氢呋喃和甲苯咪唑治疗后对人混合蠕虫感染的抗虫活性的影响。3个实验组，每组50例，对照组50例，采用安慰剂试验，纳入标准和排除标准由寄生虫学家筛选混合蠕虫感染症状样本。对首剂槟榔、四氢呋喃、甲苯达唑治疗后的不良反应进行调查，经医师和药师确认。收集槟榔治疗前后的不良反应数据。还有安慰剂。结果表明，槟榔提取物具有较好的抗氧化活性。腹泻20%，恶心20%，甲苯达唑组腹泻20%，四氢呋喃组腹泻0%。本研究建议在泰国增加蠕虫感染患者的样本数量和地点数量，以获得不同种类的蠕虫。关键词:TTHF(泰国传统草药配方);甲苯咪唑;槟榔;副作用;Antihelmintic活动

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Advances in Natural Science

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