In silico identification of epitopes target of humoral response against Sphingomyelinase 2 (Sph2) of pathogenic Leptospira

Abstract

1, a similar pattern of peptide 2, where 5% of the non-reactive samples (4) presented antibodies against this peptide. Conclusion: Through immunoinformatics it was possible to identify 2 epitopes in this protein. The ELISA tests allowed the evaluation of the immunogenicity of peptides 1 and 2 against antibodies present in the serum of patients. We believe that this study can contribute to advances in vaccine research against leptospirosis.