Histopathological relevance in clinical spectrum of Hansen's disease.

Abstract

Background: Hansen’s disease/Leprosy is one of major health problem in India, caused by Mycobacterium leprae. Diagnosed clinically based on standard Ridley Jopling’s diagnostic criteria. The clinical diagnosis and histopathological diagnosis were compared for each patient for concordance. Aim: To study clinical correlation with histopathological diagnosis of Hansen’s disease at district hospital, Warangal, Telangana state, India. Methods: Seventy five untreated patients were selected, after detailed history & clinical examination classified clinically based on Ridley & Jopling classification and 6mm punch biopsy specimen were collected, formalin fixed, sent for Haematoxylin & Eosin stain and Fite faraco stains for type of leprosy and Acid Fast Bacilli(lepra) respectively which will aid in correlating clinical diagnosis with histopathological diagnosis. Results: The clinical diagnosis based on Ridley and Jopling classification criteria were majority of them are BT(44 cases), followed by LL(15), BL(9), TT(6) and BB(1). The histopathological diagnosis showed majority of them are BT(39), BL(11), LL(10), TT(7), Indeterminate(3) & No evidence of leprosy(5) Conclusion: The clinical and histo-pathological diagnosis shown correlation in 42 cases (56%). The concordance in different spectrum of leprosy showed is TT-33%, BT-65.9%, BB-0%, BL-22.2% and LL-60% respectively.