Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.

IF 2.3 4区 医学 Q3 ONCOLOGY
Pathology & Oncology Research Pub Date : 2023-03-03 eCollection Date: 2023-01-01 DOI:10.3389/pore.2023.1610983
Ni Zhao, Nan Mei, Ye Yi, Hongyan Wang, Yajian Wang, Yu Yao, Chunli Li
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Abstract

Objectives: Pancreatic undifferentiated carcinoma accounts for 2%-7% of pancreatic carcinomas. We aimed to investigate the pathological and genetic characteristics of pancreatic undifferentiated carcinoma with osteoclast-like giant cells and the key points of treatment. Methods: The clinical data and follow-up results of four patients diagnosed with pancreatic undifferentiated carcinoma with osteoclast-like giant cells between May 2015 and May 2020 at the First Affiliated Hospital of Xi'an Jiaotong University were retrospectively analyzed. Results: Chief complaints included "pain and discomfort in the upper abdomen" (2/4), "nausea and vomiting" (1/4) or no symptoms (1/4). Preoperative mildly elevated tumor markers included carcinoembryonic antigen (1/4) and CA19-9 (1/4). The tumors were located in the tail of the pancreas in three patients and the head and neck in one patient. Tumor metastasis was found in pancreatic adipose tissue in two patients and lymph node metastasis in one patient, with microscopic heterogeneous mononuclear cells and scattered osteoclast-like giant cells of various sizes. One patient (1/4) had a mucinous cystic tumor of the pancreas, and two patients (2/4) had adenocarcinoma of the pancreatic duct. Only one patient received postoperative gemcitabine combined with albumin-bound paclitaxel chemotherapy. Conclusion: Currently, treatment guidelines are lacking for PUC-OGC, and prognosis varies markedly. More cases must be reported to clarify its origination. The long-term follow-up of diagnosed patients and genetic mutation testing can also contribute to improving treatment and prognosis of this disease.

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病例报告:带有破骨细胞样巨细胞的胰腺未分化癌的病理和遗传特征。
目的:胰腺未分化癌占胰腺癌的 2%-7%。我们旨在研究胰腺未分化癌伴破骨细胞样巨细胞的病理和遗传特征以及治疗要点。方法回顾性分析西安交通大学第一附属医院2015年5月至2020年5月期间确诊的4例胰腺未分化癌伴破骨细胞样巨细胞患者的临床资料和随访结果。结果主诉包括 "上腹部疼痛不适"(2/4)、"恶心呕吐"(1/4)或无症状(1/4)。术前肿瘤标志物轻度升高,包括癌胚抗原(1/4)和CA19-9(1/4)。三名患者的肿瘤位于胰腺尾部,一名患者的肿瘤位于头颈部。在两名患者的胰腺脂肪组织和一名患者的淋巴结转移处发现了肿瘤转移灶,显微镜下可见异型单核细胞和散在的大小不等的破骨细胞样巨细胞。一名患者(1/4)患有胰腺粘液性囊肿,两名患者(2/4)患有胰管腺癌。只有一名患者术后接受了吉西他滨联合白蛋白结合紫杉醇化疗。结论:目前,缺乏针对 PUC-OGC 的治疗指南,且预后差异明显。必须报告更多病例,以澄清其起源。对确诊患者的长期随访和基因突变检测也有助于改善该病的治疗和预后。
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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
134
审稿时长
4-8 weeks
期刊介绍: Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.
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