The Role of Platelets in Viral Hemorrhagic Fevers

Abstract

very difficult to identify the causative agent, as most VHFs have similar presentations. Even if there were anti-viral agents available, they would be unlikely to be effective against all agents, as the viruses are from different families. However, a common factor with all of these viruses is their ability to evade the innate immune system and compromise platelet function. Thus, platelets are a potential drug target in the treatment of VHFs. Therefore, the study of the role of platelets in the VHF pathogenesis may lead to the identification of new drug targets that will not only inhibit viral replication, but will also improve the antiviral immune response, preventing the onset of the hemorrhagic disease. While targeting the platelet may not inhibit viral replication, it may provide time for the immune system to clear the virus, and thereby, preventing the onset of hemorrhagic fever.