Arthrose : des traitements à venir aux traitements d’avenir

Vianney Delplace , Marie-Astrid Boutet , Catherine Le Visage , Yves Maugars , Jérôme Guicheux , Claire Vinatier
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引用次数: 0

Abstract

Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is constantly increasing. While there is no effective treatment to date, new promising therapeutic strategies and targets are being investigated. Innovative cell therapies are reaching clinical trials, and the most recent progress in our understanding of the pathology is opening new routes for gene therapy. In the long term, the development of new biofabrication tools such as 3D bioprinting might pave the way for the use of personalized mini-joint models that would allow clinicians to screen drugs and personalize treatments. This review offers an overview of the most promising therapeutic approaches in the field of osteoarthritis, from coming treatments to those that are yet to be discovered.

骨关节炎:从未来的治疗到未来的治疗
骨关节炎影响全球数亿人,其患病率不断上升。虽然迄今为止没有有效的治疗方法,但正在研究新的有希望的治疗策略和靶点。创新的细胞疗法正在进入临床试验阶段,我们对病理学的理解的最新进展为基因治疗开辟了新的途径。从长远来看,新的生物制造工具的发展,如3D生物打印,可能会为个性化微型关节模型的使用铺平道路,这将使临床医生能够筛选药物和个性化治疗。本文综述了骨关节炎领域最有前途的治疗方法,从即将到来的治疗方法到尚未发现的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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