Myeloid Sarcoma of the Urinary Bladder Associated With t(8;21): Case Report and Review of the Literature

IF 0.2
María L Suárez-Solís, F. G. González Fernández, J. Barrera Ortega, N. Pérez Romero, María García Roa, M. F. Fernández Aceñero, Freddy Fernando Durán Botia, L. Ortega Medina
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引用次数: 0

Abstract

Myeloid sarcoma is a malignant neoplasm of myeloid lineage that occurs in extramedullary sites, frequently in patients with acute myeloid leukemia and other myeloproliferative and myelodysplastic syndromes. Myeloid sarcoma of the urinary bladder is exceptionally rare, and although themost common cytogenetic abnormality associated with this lesion is t(8;21)/RUNXRUNX1T1, to the best of our knowledge, there are no previous reports of this in patients with bladder involvement. We report a case of a 30-year-old man with a urinary bladder mass, which was consistent with myeloid sarcomawith t(8;21). The importance of myeloid sarcoma of the bladder is that it could be misdiagnosed and must be differentiated from other poorly differentiated bladder tumors composed of round cells, mainly because it is amalignant neoplasm with a good response to treatment, which does not require surgery.
膀胱髓样肉瘤伴t(8;21):病例报告及文献复习
髓系肉瘤是一种发生在髓外部位的髓系恶性肿瘤,常见于急性髓系白血病和其他骨髓增生性和骨髓增生异常综合征患者。膀胱髓样肉瘤极为罕见,尽管与此病变相关的最常见的细胞遗传学异常是t(8;21)/RUNXRUNX1T1,但据我们所知,在累及膀胱的患者中尚无此类报道。我们报告一例30岁男性膀胱肿块,符合髓系肉瘤伴t(8;21)。膀胱髓样肉瘤的重要性在于它可能被误诊,必须与其他由圆形细胞组成的低分化膀胱肿瘤鉴别,主要是因为它是一种恶性肿瘤,治疗效果好,不需要手术治疗。
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期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
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