Hair cortisol in drug-naïve first-episode individuals with psychosis

E. H. Andrade, L. Rizzo, Cristiano Noto, V. Ota, A. Gadelha, L. Daruy-Filho, B. D. C. Tasso, R. Mansur, Q. Cordeiro, S. Belangero, R. Bressan, R. Grassi‐Oliveira, E. Brietzke
{"title":"Hair cortisol in drug-naïve first-episode individuals with psychosis","authors":"E. H. Andrade, L. Rizzo, Cristiano Noto, V. Ota, A. Gadelha, L. Daruy-Filho, B. D. C. Tasso, R. Mansur, Q. Cordeiro, S. Belangero, R. Bressan, R. Grassi‐Oliveira, E. Brietzke","doi":"10.1590/1516-4446-2014-1634","DOIUrl":null,"url":null,"abstract":"Objectives: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. Methods: Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. Results: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F1.106 = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. Conclusions: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1516-4446-2014-1634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16

Abstract

Objectives: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. Methods: Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. Results: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F1.106 = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. Conclusions: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission.
头发皮质醇drug-naïve首发精神病患者
目的:比较drug-naïve首发精神病(FEP)患者与健康对照者毛发皮质醇浓度(HCC),探讨HCC与精神病理的相关性。方法:招募24例drug-naïve FEP患者和27例性别、年龄匹配的健康对照。采用DSM-IV (SCID-1)结构化临床访谈来确认/排除诊断,采用阳性和阴性症状量表(PANSS)评估症状严重程度。考虑到头发生长速度为每月1厘米,从头皮后顶点区域获得的头发样本(2-3厘米长)以1厘米为段进行处理。1厘米的节段根据其与头皮的接近程度进行分类:A节段最接近头皮,指的是纳入研究前一个月。B段和C段分别指评估时间前的第2个月和第3个月。毛发类固醇提取采用已知方案。结果:以性别和年龄为协变量的双向协方差分析(ANCOVA)显示HCC存在组效应(F1.106 = 4.899, p = 0.029)。段间差异与PANSS总分、PANSS一般精神病理量表和总分相关。结论:我们的研究结果表明,长期(3个月)皮质醇浓度评估的下丘脑-垂体-肾上腺(HPA)轴在精神病的早期阶段是异常的。肝细胞癌在FEP前随时间变化的程度与精神病理相关。下丘脑轴异常可能在需要住院的全面临床表现之前就开始了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信