Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation.

IF 11.3 1区 医学 Q1 Medicine
Avery Rui Sun, Qili Sun, Yansong Wang, Liqiu Hu, Yutong Wu, Fenbo Ma, Jiayi Liu, Xiangchao Pang, Bin Tang
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引用次数: 3

Abstract

Background: Titanium (Ti) is now widely used as implant material due to its excellent mechanical properties and superior biocompatibilities, while its inert bioactivities might lead to insufficient osseointegration, and limit its performance in dental applications.

Methods: We introduced a robust and simple approach of modifying titanium surfaces with polysaccharide complexes. Titanium samples were subjected to hydrothermal treatment to create a uniform porous structure on the surface, followed by coating with a bioinspired and self-assembly polydopamine layer. Strontium Eucommia Ulmoides Polysaccharide (EUP-Sr) complexes are then introduced to the polydopamine-coated porous titanium. Multiple morphological and physiochemical characterizations are employed for material evaluation, while cell proliferation and gene expression tests using macrophages, primary alveolar bone osteoblasts, and vascular endothelial cells are used to provide an overall insight into the functions of the product. The significances of statistical differences were analyzed using student's t-test.

Results: Microscopic and spectrometric characterizations confirmed that the Ti surface formed a porous structure with an adequate amount of EUP-Sr loading. The attachment was attributed to hydrogen bonding between the ubiquitous glycosidic linkage of the polysaccharide complex and the ring structure of polydopamine, yet the loaded EUP-Sr complex can be gradually released, consequently benefiting the neighboring microenvironment. Cell experiments showed no cytotoxicity of the material, and the product showed promising anti-inflammation, osseointegration, and angiogenesis properties, which were further confirmed by in vivo evaluations.

Conclusion: We believe the EUP-Sr modified titanium implant is a promising candidate to be used in dental applications with notable osteoimmunomodulation and angiogenesis functions. And the novel technique proposed in this study would benefit the modification of metal/inorganic surfaces with polysaccharides for future research.

Abstract Image

Abstract Image

Abstract Image

杜仲锶对钛牙种植体表面改性促进骨整合和抑制炎症的研究。
背景:钛(Ti)因其优异的力学性能和良好的生物相容性而被广泛应用于种植体材料,但其惰性的生物活性可能导致其骨整合不足,限制了其在牙科领域的应用。方法:介绍了一种用多糖配合物修饰钛表面的简便易行的方法。钛样品经过水热处理,在表面形成均匀的多孔结构,然后涂覆生物启发和自组装的聚多巴胺层。然后将杜仲多糖锶(EUP-Sr)配合物引入到聚多巴胺包被的多孔钛中。多种形态和物理化学表征用于材料评估,而使用巨噬细胞、初级肺泡骨成骨细胞和血管内皮细胞的细胞增殖和基因表达测试用于全面了解产品的功能。统计学差异的显著性采用学生t检验。结果:显微镜和光谱表征证实钛表面形成多孔结构,并有足够的EUP-Sr负载。这种附着归因于多糖复合物中普遍存在的糖苷键与聚多巴胺环结构之间的氢键,但负载的EUP-Sr复合物可以逐渐释放,从而使邻近的微环境受益。细胞实验结果表明,该材料没有细胞毒性,并且该产品具有良好的抗炎症、骨整合和血管生成特性,这在体内评价中得到了进一步证实。结论:EUP-Sr改性钛种植体具有显著的骨免疫调节和血管生成功能,是一种很有前景的牙用种植体。本研究提出的新技术为今后金属/无机表面多糖修饰的研究提供了新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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