Katrin E Giel, Cynthia M Bulik, Fernando Fernandez-Aranda, Phillipa Hay, Anna Keski-Rahkonen, Kathrin Schag, Ulrike Schmidt, Stephan Zipfel
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引用次数: 0
Abstract
Binge eating disorder (BED) is characterized by regular binge eating episodes during which individuals ingest comparably large amounts of food and experience loss of control over their eating behaviour. The worldwide prevalence of BED for the years 2018-2020 is estimated to be 0.6-1.8% in adult women and 0.3-0.7% in adult men. BED is commonly associated with obesity and with somatic and mental health comorbidities. People with BED experience considerable burden and impairments in quality of life, and, at the same time, BED often goes undetected and untreated. The aetiology of BED is complex, including genetic and environmental factors as well as neuroendocrinological and neurobiological contributions. Neurobiological findings highlight impairments in reward processing, inhibitory control and emotion regulation in people with BED, and these neurobiological domains are targets for emerging treatment approaches. Psychotherapy is the first-line treatment for BED. Recognition and research on BED has increased since its inclusion into DSM-5; however, continuing efforts are needed to understand underlying mechanisms of BED and to improve prevention and treatment outcomes for this disorder. These efforts should also include screening, identification and implementation of evidence-based interventions in routine clinical practice settings such as primary care and mental health outpatient clinics.
暴饮暴食症(BED)的特征是经常性的暴饮暴食发作,在此期间,患者会摄入相当大量的食物,并对进食行为失去控制。据估计,2018-2020 年全球成年女性的暴食症患病率为 0.6-1.8%,成年男性为 0.3-0.7%。BED 通常与肥胖以及躯体和精神健康并发症相关。BED 患者的生活负担和生活质量受到严重影响,同时,BED 常常未被发现和治疗。BED 的病因复杂,包括遗传和环境因素以及神经内分泌和神经生物学因素。神经生物学研究结果表明,BED 患者在奖赏处理、抑制控制和情绪调节方面存在障碍,这些神经生物学领域是新兴治疗方法的目标。心理治疗是 BED 的一线治疗方法。自 BED 被纳入 DSM-5 以来,对 BED 的认识和研究不断增加;然而,我们仍需继续努力,以了解 BED 的潜在机制,并改善这种疾病的预防和治疗效果。这些努力还应包括在常规临床实践环境(如初级保健和心理健康门诊)中筛查、识别和实施循证干预措施。
期刊介绍:
Nature Reviews Disease Primers, a part of the Nature Reviews journal portfolio, features sections on epidemiology, mechanisms, diagnosis, management, and patient quality of life. The editorial team commissions top researchers — comprising basic scientists and clinical researchers — to write the Primers, which are designed for use by early career researchers, medical students and principal investigators. Each Primer concludes with an Outlook section, highlighting future research directions. Covered medical specialties include Cardiology, Dermatology, Ear, Nose and Throat, Emergency Medicine, Endocrinology, Gastroenterology, Genetic Conditions, Gynaecology and Obstetrics, Hepatology, Haematology, Infectious Diseases, Maxillofacial and Oral Medicine, Nephrology, Neurology, Nutrition, Oncology, Ophthalmology, Orthopaedics, Psychiatry, Respiratory Medicine, Rheumatology, Sleep Medicine, and Urology.