Diffusive exit rates through pores in membrane-enclosed structures.

IF 2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Physical biology Pub Date : 2023-01-24 DOI:10.1088/1478-3975/acb1ea

Zitao Yang, Elena F Koslover

引用次数: 1

Abstract

The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the channel. We propose a simple approximate model, validated with stochastic simulations, for estimating the effective release rate from cylinders, and other simple-shaped domains, as a function of channel parameters. The results demonstrate that, for very small pores, a low density of channels scattered over the boundary is sufficient to achieve substantial rates of particle release. Furthermore, we show that increasing the length of passive channels will both reduce release rates and lead to a less steep dependence on channel density. Our results are compared to previously-measured local calcium release rates from tubules of the endoplasmic reticulum, providing an estimate of the relevant channel density responsible for the observed calcium efflux.

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在膜封闭结构中通过孔的扩散出口率。

许多膜封闭的细胞内结构的功能依赖于扩散颗粒的释放，这些颗粒通过膜上的狭窄孔或通道排出。释放速率随孔道的大小、密度和长度而变化。我们提出了一个简单的近似模型，通过随机模拟验证，用于估计圆柱体和其他简单形状域的有效释放率，作为通道参数的函数。结果表明，对于非常小的孔隙，分散在边界上的低密度通道足以实现大量的颗粒释放。此外，我们表明，增加被动通道的长度既可以降低释放率，又可以减少对通道密度的依赖。我们的结果与先前测量的内质网小管局部钙释放率进行了比较，提供了对观察到的钙外排负责的相关通道密度的估计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physical biology 生物-生物物理

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Physical Biology publishes articles in the broad interdisciplinary field bridging biology with the physical sciences and engineering. This journal focuses on research in which quantitative approaches – experimental, theoretical and modeling – lead to new insights into biological systems at all scales of space and time, and all levels of organizational complexity. Physical Biology accepts contributions from a wide range of biological sub-fields, including topics such as: molecular biophysics, including single molecule studies, protein-protein and protein-DNA interactions subcellular structures, organelle dynamics, membranes, protein assemblies, chromosome structure intracellular processes, e.g. cytoskeleton dynamics, cellular transport, cell division systems biology, e.g. signaling, gene regulation and metabolic networks cells and their microenvironment, e.g. cell mechanics and motility, chemotaxis, extracellular matrix, biofilms cell-material interactions, e.g. biointerfaces, electrical stimulation and sensing, endocytosis cell-cell interactions, cell aggregates, organoids, tissues and organs developmental dynamics, including pattern formation and morphogenesis physical and evolutionary aspects of disease, e.g. cancer progression, amyloid formation neuronal systems, including information processing by networks, memory and learning population dynamics, ecology, and evolution collective action and emergence of collective phenomena.