Vestibular & Balance Assessment in Hepatitis C Virus Patients Undergoing (Sovaldi/Daklinza) Regimen

Q4 Medicine

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Pub Date : 2022-01-01 DOI:10.21608/ejentas.2021.69389.1339

Aya Elhusseiny, A. Shalaby, H. Taha, O. Ahmed

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Abstract

Department of 1,2,3Audiology, E.N.T, 4Internal Medicine, Hepatogastroenterology Unit, Faculty of Medicine, Ain Shams University, Egypt. ABSTRACT Background: Previous Hepatitis C Virus (HCV) antiviral drugs reported to cause ototoxicity. Aim: To detect any possible adverse effects of Sovaldi/ Daklinza regimen related to vestibular & balance functions. Patients and Methods: Vestibular & balance were assessed in a total number of thirty adult HCV patients , ranging from twenty to sixty years old before administration of (Sovaldi/Daklinza) and three months later , using Vestibular office tests (Head shake test, Head thrust test, Fukuda stepping test& one leg stance). Videonystagmography (VNG), Sensory organization test (SOT) of Dynamic posturagraphy. Results: After treatment, all patients had normal vestibular office tests, normal VNG testing except for three patients (10% of the study sample) showed positional nystagmus after treatment that wasn’t present before receiving Sovaldi/ Daclinza & normal balance function as demonstrated by SOT of Dynamic posturagraphy, with non-statistical significant difference when comparing before and after treatment findings. Conclusion: Sovaldi/Daklinza regimen used in HCV treatment has no statistically significant effect on vestibular & balance function.

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丙型肝炎病毒患者接受(Sovaldi/Daklinza)治疗方案的前庭和平衡评估

埃及艾因沙姆斯大学医学院1、2、3听力学、耳鼻喉科、4内科、肝消化内科背景:既往丙型肝炎病毒(HCV)抗病毒药物有引起耳毒性的报道。目的:检测Sovaldi/ Daklinza治疗方案对前庭及平衡功能可能产生的不良反应。患者和方法:对30例年龄在20 - 60岁的成人HCV患者进行前庭和平衡评估，分别在服用(Sovaldi/Daklinza)前和服用3个月后，采用前庭办公室测试(头部摇晃测试、头部推力测试、福田踏步测试和单腿站立)。动态体位术的视震仪(VNG)、感觉组织测试(SOT)。结果:治疗后，所有患者前庭办公室检查正常，VNG检查正常，除3例(占研究样本的10%)患者在接受Sovaldi/ Daclinza治疗前未出现的治疗后体位性眼球震颤和动态体位摄影SOT显示平衡功能正常外，治疗前后比较无统计学意义。结论:Sovaldi/Daklinza方案治疗HCV对前庭及平衡功能无显著影响。

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来源期刊

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Medicine-Otorhinolaryngology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： Egyptian Journal of Ear, Nose, Throat and Allied Sciences aspires to play a national, regional and international role in the promotion of responsible and effective research in the field of Otolaryngology, Head and Neck Surgery in Egypt, Middle East and Africa. Mission To encourage and support research in Ear, Nose and Throat (ENT) field and interdisciplinary topics To implement high-quality editorial practices among Otolaryngologists To upgrade the ability and experience of local doctors in international publishing To offer professional publishing support to local researchers, creating a supportive network for career development To highlight ENT diseases and problems peculiar to our region To promote research in endemic, hereditary and infectious ENT problems related to our region To expose and study impact of ethnic, social, environmental and cultural issues on expression of different ENT diseases To organize common epidemiologic research of value to the region To provide resource to national and regional authorities about problems in the field of ENT and their implication on public health and resources To facilitate exchange of knowledge in our part of the world To expand activities with regional and international scientific societies.