Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467215666220520143124

Serkan Yilmaz

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引用次数: 3

Abstract

Background: Acne is a chronic inflammatory disease mainly observed in adolescence, but it can also be seen during the neonatal, infantile, pre-pubertal, and adult periods. Isotretinoin (13-cis-retinoic acid) is a first-generation retinoid and is the most effective treatment for acne vulgaris.

Objective: The present study has been systematically designed to figure out the toxic, genotoxic, and carcinogenic activities of isotretinoin.

Methods: In this study, a systematic approach was followed by focusing on the possible links between these topics. The search of the databases was carried out author in accordance with the guidelines of the Centre for Reviews and Dissemination (2009) developed by York University National Institute of Health Research. The search was concentrated on the Web of Science, PubMed, Science Direct, Scopus, EBSCO Host, and Google Scholar databases.

Results: Isotretinoin was found as a toxic agent in all studies. All researchers proposed that apoptosis is the only pathway of adverse effects of isotretinoin. However, genotoxicity, teratogenicity, and carcinogenicity information of isotretinoin is very limited and controversial.

Conclusion: More detailed studies need to clarify the genotoxic and carcinogenic potential of isotretinoin. Patients should be informed correctly, the risks of treatment should be explained, and awareness should be raised.

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异维a酸的毒性、遗传毒性和致癌性。

背景:痤疮是一种主要发生于青春期的慢性炎症性疾病，但在新生儿、婴儿期、青春期前和成人期也可发生。异维甲酸(13-顺式维甲酸)是第一代类维甲酸，是治疗寻常痤疮最有效的药物。目的:系统地研究异维甲酸的毒性、遗传毒性和致癌性。方法:在本研究中，采用系统的方法，重点关注这些主题之间的可能联系。数据库的检索是根据约克大学国家卫生研究所制定的审查和传播中心(2009年)的指导方针进行的。搜索集中在Web of Science、PubMed、Science Direct、Scopus、EBSCO Host和Google Scholar数据库上。结果:在所有研究中均发现异维a酸是一种有毒物质。所有研究者都认为细胞凋亡是异维a酸不良反应的唯一途径。然而，关于异维甲酸的遗传毒性、致畸性和致癌性的信息非常有限，且存在争议。结论:需要更详细的研究来阐明异维甲酸的遗传毒性和致癌潜力。应该正确告知患者，解释治疗的风险，并提高认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.