Vitamin C And Vitamin E Supplementation In Pregnant Women At Risk For Pre Eclampsia : A Randomized Controlled Trial.

Abstract

Evidence suggests that antioxidant supplementation reduces risk of preeclampsia. Our aim was to investigate the potential benefit of antioxidants in women with risk factors of preeclampsia. A total of 285women identified at risk of preeclampsia were administered vitamin C 1000 mg, vitamin E 200mg / placebo from 12 weeks of pregnancy till delivery in intention to treat. The patients were randomly assigned to drug groups. The Incidence of preeclampsia, intrauterine growth retardation, and caesarean between placebo and vitamin group were compared and were found to be same. But preterm birth reduced in statistically significant number in vitamin group (OR = 0.28, CI = 0.21 - 0.99, p = 0.01).