Infertility Does Not Increase the Rate of Breast Fibroadenoma.

Q2 Medicine
Mandana Motamedi, Ashraf Moini, Khadije Maajani, Arezoo Maleki-Hajiagha, Sadaf Alipour
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Abstract

Background: Fibroadenoma (FA) and infertility can share common risk factors and probably common underlying pathophysiology, but yet there is no study evaluating the prevalence of FA in infertile women. Therefore, the aim of in the present study, the purpose was evaluating the association of FA and infertility for the first time.

Methods: This short communication is a secondary analysis of a primary study that was performed in Arash Women's Hospital, Tehran, Iran. Participants were selected among reproductive-aged women with a history of infertility as the case and women without infertility as the control group. The criteria for diagnosis of FA were histopathologic assessment for lumps 1 cm in size or larger, and a typical ultrasound image for smaller lumps. Assisted reproductive technology (ART) was defined as any previous history of undergoing ovulation stimulation, intrauterine insemination, intracytoplasmic sperm injection, or in vitro fertilization.

Results: Overall, 155 cases with a mean age of 39.2±6.9, and 167 controls with a mean age of 43.08±8.3 were included (p=0.0001). Interestingly, the incidence of FA was lower in the case group (18.7% vs. 25.7%), however, the difference was not statistically significant (p=0.13). Also, logistic regression analysis showed that the chance for an infertile woman who undergoes ART to get FA is 1.7 times higher in comparison to non-ART group, although the difference was not significant (p=0.21).

Conclusion: Infertility and ART were not associated with increased risk of FA; however, larger prospective studies should be conducted in the future in order to achieve conclusive results.

不孕不会增加乳腺纤维腺瘤的发生率。
背景:纤维腺瘤(FA)和不孕有共同的危险因素,可能有共同的潜在病理生理学,但目前还没有研究评估不孕妇女中FA的患病率。因此,本研究的目的是首次评估FA与不孕的关系。方法:这篇简短的交流是对伊朗德黑兰Arash妇女医院进行的一项初步研究的二次分析。参与者是从有不孕病史的育龄妇女和没有不孕的妇女中选择的作为对照组。FA的诊断标准是对1cm或更大肿块的组织病理学评估,以及对较小肿块的典型超声图像。辅助生殖技术(ART)被定义为任何既往经历过排卵刺激、宫内受精、卵浆内精子注射或体外受精的病史。结果:总的来说,包括155例平均年龄为39.2±6.9的病例和167例平均年龄43.08±8.3的对照组(p=0.0001)。有趣的是,病例组FA的发生率较低(18.7%对25.7%),但差异无统计学意义(p=0.013)。此外,logistic回归分析显示,与非ART组相比,接受ART的不孕妇女获得FA的几率高1.7倍,但差异不显著(p=0.21)。结论:不孕和ART与FA风险增加无关;然而,为了取得决定性的结果,未来应该进行更大规模的前瞻性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Reproduction and Infertility
Journal of Reproduction and Infertility Medicine-Reproductive Medicine
CiteScore
2.70
自引率
0.00%
发文量
44
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