Elevated homocysteine and crises state in patients with sickle cell anemia: A comparative study

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
A. Orolu, T. Adeyemo, Alani S Akanmu
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Abstract

Background: High plasma concentration of homocysteine (Hcy) is a well-established risk factor for several disorders, including cardiovascular disease, stroke, venous thrombosis, and arteriosclerosis. Folic acid deficiency leads to an increase in homocysteine. This study aimed to test whether elevated serum homocysteine, diminished folate, and B12 levels correlate with the frequency of crisis in sickle cell disease (SCD). Methods: This was a comparative cross-sectional study conducted on 110 adults consisting of participants with SCD in vaso-occlusive crises (VOC), SCD in hyperhemolytic crises (HHC), SCD in steady-state (SS), and healthy controls. Serum homocysteine, folate, and B12 levels were determined using the Enzyme-linked immunosorbent assay method. The level of statistical significance was defined as P < 0.05, at a 95% confidence interval. Results: The mean age of all participants was 25.5 ± 5.8 years. There was a statistically significant difference in mean serum homocysteine levels with mean levels of (11.9 ± 4.5, 13.1 ± 5.4, 10.3 ± 2.3, 9.9 ± 2.5 μmol/L) in participants in VOC, HHC, SS, and controls, respectively (P = 0.016). With a cut-off of <15 μmol/L, hyperhomocysteinemia was seen in 31.% and 26.7% of participants in HHC and VOC, respectively. Conversely, no participant in the SS or the control group had hyperhomocysteinemia. Serum folate (nmol/L) level was lower, though not significantly, in the HHC group than in the other groups, with 9.9 ± 5.5 versus 12.7 ± 6.8, 11.8 ± 4.1 and 12.7 ± 2.2 nmol/L for the VOC, SS, and control group, respectively (P = 0.121). A significant inverse correlation was found between homocysteine and folate (correlation coefficient − 0.589 and P < 0.001) in all study participants. Conclusion: This study reveals significantly higher homocysteine levels in participants with sickle anemia in vaso-occlusive and hyperhemolytic crises (HHCs), highlighting homocysteine and folate role in the pathogenesis of these events.
镰状细胞性贫血患者同型半胱氨酸升高与危象状态的比较研究
背景:高血浆同型半胱氨酸(Hcy)浓度是几种疾病的一个公认的危险因素,包括心血管疾病、中风、静脉血栓形成和动脉硬化。叶酸缺乏会导致同型半胱氨酸增加。本研究旨在检测血清同型半胱氨酸升高、叶酸和B12水平降低是否与镰状细胞病(SCD)危重发生频率相关。方法:这是一项对110名成人进行的比较横断面研究,包括血管闭塞危化期(VOC) SCD、高溶血危化期(HHC) SCD、稳态(SS) SCD和健康对照。采用酶联免疫吸附法测定血清同型半胱氨酸、叶酸和B12水平。以P < 0.05定义统计学显著性水平,置信区间为95%。结果:所有参与者的平均年龄为25.5±5.8岁。VOC组、HHC组、SS组和对照组的平均血清同型半胱氨酸水平分别为(11.9±4.5、13.1±5.4、10.3±2.3、9.9±2.5 μmol/L),差异有统计学意义(P = 0.016)。截止值<15 μmol/L时,31例患者出现高同型半胱氨酸血症。HHC和VOC的参与者分别为%和26.7%。相反,没有参与者在SS或对照组有高同型半胱氨酸血症。血清叶酸(nmol/L)水平在HHC组低于其他组,但差异不显著,VOC组为9.9±5.5,SS组为12.7±6.8,11.8±4.1和12.7±2.2 nmol/L,对照组为12.7±2.2 nmol/L (P = 0.121)。在所有研究参与者中,同型半胱氨酸和叶酸之间存在显著的负相关(相关系数为- 0.589,P < 0.001)。结论:本研究揭示了镰状贫血患者血管闭塞和高溶血危期(hhc)的同型半胱氨酸水平显著升高,强调了同型半胱氨酸和叶酸在这些事件的发病机制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
15
审稿时长
45 weeks
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