EFFECT OF AMLODIPINE ON MONOSODIUM GLUTAMATE-INDUCED CARDIAC OXIDATIVE STRESS IN RATS

Journal Of Chemical Society Of Nigeria Pub Date : 2023-04-21 DOI:10.46602/jcsn.v48i2.864

Anthony Cemaluk C. Egbuonu, P. O. Alaebo, O. Atasie, J. Obike, C. Anoliefo, G. F. Iroerunachi, E. C. Lewechukwu, I. C. Egwu, D. S. Okeohia, F. Obinna, U. Okeke, H. Nwokenna, F. N. Ndukamma, M. N. Nwaiwe, I. G. Oti

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Abstract

Monosodium glutamate, MSG, induces oxidative stress which underlies many ailments including inflammation and heart dysfunctions. Amlodipine, AML, an anti-hypertensive could result to unknown effects on the cardiac oxidative function when co-taken with MSG. This study evaluated the effect of AML against experimental MSG-induced cardiac oxidative stress. Thus, rats orally and for 14 consecutive days received MSG (8000 mg/Kg/day). Cardiac oxidative stress bio-indicators: malondialdehyde, MDA, nitric oxide, NOX, glutathione peroxidase, GPX, superoxide dismutase, SOD, catalase, CAT, albumin, ALB, total protein, TP, magnesium, Mg, and zinc, Zn were determined. MSG significantly (p < 0.05) increased MDA and Zn but decreased others without altering NOX content compared to control rats in consistency with induction of cardiac oxidative stress in the rats. AML dose-dependently mitigated these MSG-induced oxidative effects. Thus, AML can protect against MSG-induced cardiac oxidative stress in the rats. Keywords: Monosodium glutamate, Amlodipine, Oxidative stress, Heart, Nitric oxide

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氨氯地平对谷氨酸钠诱导大鼠心脏氧化应激的影响

谷氨酸钠(味精)会引起氧化应激，这是许多疾病的基础，包括炎症和心脏功能障碍。抗高血压药物氨氯地平与味精合用对心脏氧化功能的影响尚不清楚。本研究评估了急性髓性白血病(AML)对实验性msg诱导的心脏氧化应激的影响。因此，大鼠连续14天口服味精(8000 mg/Kg/天)。测定心脏氧化应激生物指标:丙二醛、MDA、一氧化氮、NOX、谷胱甘肽过氧化物酶、GPX、超氧化物歧化酶、SOD、过氧化氢酶、CAT、白蛋白、ALB、总蛋白、TP、镁、Mg、锌、Zn。与对照大鼠相比，味精显著(p < 0.05)提高了MDA和Zn，降低了其他两种(p < 0.05)，但未改变NOX含量，这与诱导大鼠心脏氧化应激一致。AML剂量依赖性地减轻了这些味精诱导的氧化作用。因此，AML可以保护大鼠免受msg诱导的心脏氧化应激。关键词:谷氨酸钠，氨氯地平，氧化应激，心脏，一氧化氮

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Journal Of Chemical Society Of Nigeria

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