Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations.

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2022-12-01
Clio Dessinioti, Andreas Katsambas
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引用次数: 0

Abstract

Antimicrobial resistance is an increasing public health problem worldwide. The interest of a focus on antimicrobial resistance in acne lies on the facts that acne vulgaris (acne) is the most common skin disease worldwide, that the bacterium Cutibacterium acnes (C. acnes, formerly Propionibacterium acnes) plays a key role in the pathogenesis of acne, while at the same time being part of the skin flora, and that antibiotics are commonly recommended for acne treatment. The overuse of topical and/or systemic antibiotics, the long treatment courses used for acne, and the availability of over-the-counter antibiotic preparations, have led to the worldwide emergence of resistant strains in acne patients. In this review, we discuss the epidemiological trends of antimicrobial resistance in acne, the need to avoid the perturbation of the skin microbiome caused by anti-acne antibiotics, and the clinical practice considerations related to the emergence of resistant strains in acne patients. In light of the increasing risk of antimicrobial resistance, raising concerns over the misuse of antibiotics, prescribing patterns can be a critical target for antibiotic stewardship efforts. Also, the selection of non-antibiotic therapies for acne, whenever possible, may offer significant advantages.

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痤疮的抗生素和抗菌素耐药性:流行病学趋势和临床实践考虑。
抗菌素耐药性是世界范围内日益严重的公共卫生问题。关注痤疮抗菌素耐药性的兴趣在于普通痤疮(痤疮)是世界范围内最常见的皮肤病,痤疮角膜炎杆菌(C. acnes,原痤疮丙酸杆菌)在痤疮的发病机制中起关键作用,同时也是皮肤菌群的一部分,抗生素通常被推荐用于痤疮治疗。局部和/或全身抗生素的过度使用,痤疮的长期治疗过程,以及非处方抗生素制剂的可用性,导致了世界范围内痤疮患者中耐药菌株的出现。本文就痤疮患者抗菌药物耐药性的流行趋势、避免抗痤疮抗生素引起皮肤微生物群紊乱的必要性以及痤疮患者出现耐药菌株的临床实践注意事项进行综述。鉴于抗菌素耐药性的风险日益增加,引起了对抗生素滥用的关注,处方模式可以成为抗生素管理工作的一个关键目标。此外,选择非抗生素治疗痤疮,只要可能,可能提供显著的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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