Peter N Johnson, Katy Stephens, Philip Barker, Erica Bergeron, Sin Yin Lim, Tracy M Hagemann, Teresa V Lewis, Stephen Neely, Jamie L Miller
{"title":"Prescribing Patterns of Continuous Infusions in Nonobese versus Obese Children Admitted to the Pediatric Intensive Care Unit.","authors":"Peter N Johnson, Katy Stephens, Philip Barker, Erica Bergeron, Sin Yin Lim, Tracy M Hagemann, Teresa V Lewis, Stephen Neely, Jamie L Miller","doi":"10.1055/s-0039-1692669","DOIUrl":null,"url":null,"abstract":"<p><p>This retrospective study compared the continuous infusions prescribed for obese and nonobese children. Ninety-five (13.2%) received an infusion. A greater percentage of obese ( <i>n</i> = 42/168) versus nonobese (53/552) children received infusions, <i>p</i> < 0.01. No difference was noted in the median number of infusions between the obese and nonobese groups, 2 versus 2, <i>p</i> = 0.975. The top 20 prescribed infusions included ten (50%) for sedation/analgesia or neuromuscular blockade and six (30%) for hemodynamic support. A literature search was performed for these 20 agents to determine pharmacokinetics, pharmacodynamics, and dosing in obese children and revealed six studies evaluating fentanyl ( <i>n</i> = 2), midazolam ( <i>n</i> = 1), and propofol ( <i>n</i> = 3).</p>","PeriodicalId":30555,"journal":{"name":"Saude Tecnologia","volume":"1 1","pages":"226-232"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821521/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saude Tecnologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0039-1692669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/6/21 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This retrospective study compared the continuous infusions prescribed for obese and nonobese children. Ninety-five (13.2%) received an infusion. A greater percentage of obese ( n = 42/168) versus nonobese (53/552) children received infusions, p < 0.01. No difference was noted in the median number of infusions between the obese and nonobese groups, 2 versus 2, p = 0.975. The top 20 prescribed infusions included ten (50%) for sedation/analgesia or neuromuscular blockade and six (30%) for hemodynamic support. A literature search was performed for these 20 agents to determine pharmacokinetics, pharmacodynamics, and dosing in obese children and revealed six studies evaluating fentanyl ( n = 2), midazolam ( n = 1), and propofol ( n = 3).
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