Monte Carlo characterization of the gold nanoparticles dose enhancement and estimation of the physical interactions weight in dose enhancement mechanism

IF 0.7 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Polish Journal of Medical Physics and Engineering Pub Date : 2020-12-01 DOI:10.2478/pjmpe-2020-0026

M. Mohammadzadeh, Hosein Ghiasi

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引用次数: 2

Abstract

Abstract Radiosensitization of the cancer cells by the heavy atoms of nanoparticles was the subject of some studies. But, the physical characterization to determine the weight of all interactions hasn’t been made numerically. The aim of this study was to calculate and compare the dose enhancement (DE) for different energies. The Monte Carlo simulation method was used in the current study. The influence of gold nanoparticles (GNP) size, beam quality, the GNP concentration, and dose inhomogeneity on the radiosensitization by DE was studied. A 35% increase in the photoelectric effect was observed while energy decreased from 18 MV to 300 kV. In the microscopic study which DE calculated in 30 µm from a single GNP, a 79% decreasing in DE within the first 1µm was seen and it declined to 2% in 30 µm from the GNP center. The effect was observed at small distances only. Our study revealed that the dose inhomogeneity around a nanoparticle is the main and very strong effect of DE on a macroscopic scale. In the location which 35% DE occurs most malignant cells survival will be effectively reduced. Our research indicates the need for further research.

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金纳米粒子剂量增强的蒙特卡罗表征及剂量增强机制中物理相互作用权重的估计

纳米粒子重原子对癌细胞的放射致敏作用是一些研究的主题。但是，确定所有相互作用权重的物理表征还没有得到数值计算。本研究的目的是计算和比较不同能量下的剂量增强(DE)。本研究采用蒙特卡罗模拟方法。研究了金纳米颗粒(GNP)尺寸、光束质量、GNP浓度和剂量不均匀性对DE放射致敏的影响。当能量从18 MV下降到300 kV时，光电效应增加了35%。在微观研究中，从单个GNP计算30 μ m的DE，在前1 μ m内，DE下降了79%，从GNP中心30 μ m内，DE下降到2%。这种效应只在很小的距离内观察到。我们的研究表明，在宏观尺度上，纳米颗粒周围的剂量不均匀性是DE的主要和非常强烈的影响。在发生35% DE的部位，大多数恶性细胞的存活率将有效降低。我们的研究表明需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polish Journal of Medical Physics and Engineering RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Polish Journal of Medical Physics and Engineering (PJMPE) (Online ISSN: 1898-0309; Print ISSN: 1425-4689) is an official publication of the Polish Society of Medical Physics. It is a peer-reviewed, open access scientific journal with no publication fees. The issues are published quarterly online. The Journal publishes original contribution in medical physics and biomedical engineering.