Effectiveness of Giving Red Ginger Extract in Preventing Damage to ß-Pancreatic Cells in Wistar Strain White Rats (Rattus Norvegicus)

Abstract

Background: One of the goals of therapy for diabetes mellitus is to maintain normal glucose levels. Therapy can be in the form of pharmacology and non-pharmacology. In addition, in the community many use traditional medicine or often known as herbal medicine for the treatment of diabetes. Traditional medicine that has many uses for treatment is ginger. The main ingredients of ginger are essential oils (1-5%), sesquiterpenoids and monoterpenoids, gingerols, shogaols, paradols and zingerones. The effects of ginger therapy are anti-inflammatory, analgesic, hypotensive and diabetic which is associated with gingerol and shogaol which are abundant in fresh ginger and ginger. Objectives: The aim of the study was to analyze the effectiveness of red ginger extract in preventing damage to s-pancreatic cells in wistar strain white rats (rattus norvegicus) Methods: This study was laboratory experimental study with randomized post-test only control group design. The independent variable was the administration of red ginger extract, the dependent variable was blood sugar levels and the control variables were rat type, rat sex, rat age, rat body weight and rat health. The samples were 25 male Wistar strain white rats aged 8–12 weeks. The samples were divided into 5 groups randomly. One group not induced by diabetes was the healthy control group (K1). The other four groups were induced by diabetes: (K2) control of diabetes; (K3) given 500 mg/kgBW of red ginger extract; (K4) given 750 mg/kgBW of red ginger extract and (K5) given 1,000 mg/kgBW of red ginger extract. ANOVA test with α=0.05 was used to determine the effect of treatment. Furthermore, an effect size test analysis was conducted to determine the effectiveness of red ginger extract Results: all of the treatment (500 mg/kgBW, 750 mg/kgBW and 1,000 mg/kgBW of red ginger extract) had strong effect on fasting blood sugar control of the mice (effec size> 1) Conclusions: the treatment where 750 mg/kgBW of red ginger extract was administered has the highest value of effectiveness (3,632), while that in which 1,000 mg / kgBB of red ginger extract was administered has the lowest value of effectiveness (1,195). Keywords: Effectiveness, red ginger, s-pancreatic cells DOI : 10.7176/JMPB/55-01 Publication date :May 31 st 2019