Acute Kidney Injury in Pediatric Patients with COVID-19; Clinical Features and Outcome.

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2023-01-01

Mahbubeh Mirzaee, Mahnaz Jamee, Masoumeh Mohkam, Fatemeh Abdollah Gorji, Mitra Khalili, Sedigheh Rafiei Tabatabaei, Abdollah Karimi, Shahnaz Armin, Roxana Mansour Ghanaie, Seyed Alireza Fahimzad, Zahra Pournasiri, Seyed Mohammad Taghi Hosseini Tabatabaei, Reza Dalirani, Nasrin Esfandiar, Mina Alibeik

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引用次数: 0

Abstract

Introduction: Renal disorders have been reported as the underlying cause as well as complications of critical COVID-19 in pediatric patients. The purpose of this study was to investigate the pattern of kidney involvement, particularly acute kidney injury (AKI), among pediatric patients with COVID-19.

Methods: In this prospective study, hospitalized pediatric patients with a clinical diagnosis of COVID-19 were enrolled. Demographic, clinical, and laboratory findings were collected and analyzed using a mixed method of qualitative and quantitative approaches and descriptive statistics.

Results: One hundred and eighty-seven patients, including 120 (64.2%) males and 67 (35.8%) females with COVID-19 with a median age (interquartile range) of 60 (24 to 114) months were enrolled in this study. Most patients (n = 108, 58.1%) had one or two underlying comorbidities, mainly malnutrition (77.4%), neurologic/learning disorders (21.4%), and malignancy (10.2%). According to the Kidney Disease Improving Global Outcomes (KDIGO) classification, AKI was detected in 38.5% of patients (stage 1: 55.6%, stage 2: 36.1%, and stage 3: 8.3%) at presentation or during hospitalization. Nine patients (4.8%) required hemodialysis and 16 (8.6%) eventually died. There was no significant association between AKI and admission to the pediatric intensive care unit (PICU) (P > .05), a multisystem inflammatory syndrome in children (MIS-C) (P > .05), comorbidities (P > .05), and mortality rate (P > .05).

Conclusion: Kidneys are among the major organs affected by COVID-19. Although kidney abnormalities resolve in the majority of pediatric COVID-19 infections, particular attention should be paid to serum creatinine and electrolyte levels in patients affected by COVID-19, particularly children with a history of malnutrition and kidney disorders. DOI: 10.52547/ijkd.7151.

本刊更多论文

小儿COVID-19急性肾损伤的研究临床特征和结果。

导语:肾脏疾病已被报道为小儿重症COVID-19的根本原因和并发症。本研究的目的是调查儿童COVID-19患者肾脏受累的模式，特别是急性肾损伤(AKI)。方法:本前瞻性研究纳入临床诊断为COVID-19的住院儿科患者。使用定性和定量方法以及描述性统计的混合方法收集和分析人口统计学、临床和实验室结果。结果:共纳入187例新冠肺炎患者，其中男性120例(64.2%)，女性67例(35.8%)，中位年龄(四分位数间距)为60(24 ~ 114)个月。大多数患者(n = 108, 58.1%)有一种或两种潜在的合并症，主要是营养不良(77.4%)、神经/学习障碍(21.4%)和恶性肿瘤(10.2%)。根据肾脏疾病改善总体结局(KDIGO)分类，38.5%的患者(1期:55.6%，2期:36.1%，3期:8.3%)在就诊或住院期间检测到AKI。9名患者(4.8%)需要血液透析，16名患者(8.6%)最终死亡。AKI与儿童重症监护病房(PICU) (P > 0.05)、儿童多系统炎症综合征(MIS-C) (P > 0.05)、合并症(P > 0.05)和死亡率(P > 0.05)之间无显著相关性。结论:肾脏是新冠病毒感染的主要脏器之一。虽然大多数儿童COVID-19感染的肾脏异常会消退，但应特别注意受COVID-19影响的患者，特别是有营养不良和肾脏疾病史的儿童的血清肌酐和电解质水平。DOI: 10.52547 / ijkd.7151。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.