Safety and Efficacy of Mesenchymal Stem Cells in Burn Therapy: Systematic Review

MCBS Molecular and Cellular Biomedical Sciences Pub Date : 2022-11-02 DOI:10.21705/mcbs.v6i3.252

Theresia Dini, Yudhi Nugraha, R. Revina, K. Karina

{"title":"Safety and Efficacy of Mesenchymal Stem Cells in Burn Therapy: Systematic Review","authors":"Theresia Dini, Yudhi Nugraha, R. Revina, K. Karina","doi":"10.21705/mcbs.v6i3.252","DOIUrl":null,"url":null,"abstract":"The experimental research on the use of mesenchymal stem cells (MSCs) for burn therapy has been published several times. However, current clinical procedure remains a challenging discussion. This systematic review assesses the safety and efficacy of administering mesenchymal stem cells (MSCs) to burns and determines the most effective source of MSCs for burn therapy. We reviewed several studies through PubMed, Google Scholar, Science Direct, and DOAJ online databases. PRISMA-P 2020 method was used based on inclusion and exclusion criteria that were re-selected through Joanna Briggs Institute (JBI) Critical Appraisal Tools. Results from 13 articles showed that MSCs are safe for burn therapy with minimal side effects/complications and have the potential to repair tissue and accelerate burn healing through several mechanisms. The treatment of MSCs in burns is influenced by donor characteristics and related to the severity and area of the burn. It can be concluded that the administration of MSCs is safe and effective in burn therapy. Keywords: burns, mesenchymal stem cells, therapeutic safety, therapeutic efficacy, wound healing","PeriodicalId":53387,"journal":{"name":"MCBS Molecular and Cellular Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MCBS Molecular and Cellular Biomedical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21705/mcbs.v6i3.252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 2

Abstract

The experimental research on the use of mesenchymal stem cells (MSCs) for burn therapy has been published several times. However, current clinical procedure remains a challenging discussion. This systematic review assesses the safety and efficacy of administering mesenchymal stem cells (MSCs) to burns and determines the most effective source of MSCs for burn therapy. We reviewed several studies through PubMed, Google Scholar, Science Direct, and DOAJ online databases. PRISMA-P 2020 method was used based on inclusion and exclusion criteria that were re-selected through Joanna Briggs Institute (JBI) Critical Appraisal Tools. Results from 13 articles showed that MSCs are safe for burn therapy with minimal side effects/complications and have the potential to repair tissue and accelerate burn healing through several mechanisms. The treatment of MSCs in burns is influenced by donor characteristics and related to the severity and area of the burn. It can be concluded that the administration of MSCs is safe and effective in burn therapy. Keywords: burns, mesenchymal stem cells, therapeutic safety, therapeutic efficacy, wound healing

查看原文本刊更多论文

间充质干细胞在烧伤治疗中的安全性和有效性:系统综述

利用间充质干细胞(MSCs)治疗烧伤的实验研究已多次发表。然而，目前的临床程序仍然是一个具有挑战性的讨论。本系统综述评估了间充质干细胞(MSCs)治疗烧伤的安全性和有效性，并确定了烧伤治疗中最有效的间充质干细胞来源。我们通过PubMed、Google Scholar、Science Direct和DOAJ在线数据库回顾了几项研究。PRISMA-P 2020方法是根据乔安娜布里格斯研究所(JBI)关键评估工具重新选择的纳入和排除标准使用的。13篇文章的结果表明，MSCs用于烧伤治疗是安全的，副作用/并发症最小，并且具有修复组织和通过几种机制加速烧伤愈合的潜力。烧伤中间充质干细胞的治疗受供体特征的影响，并与烧伤的严重程度和面积有关。由此可见，应用间充质干细胞治疗烧伤是安全有效的。关键词:烧伤，间充质干细胞，治疗安全性，治疗效果，伤口愈合

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

MCBS Molecular and Cellular Biomedical Sciences

自引率

0.00%

发文量

审稿时长

20 weeks