{"title":"Bacteriological pattern of urinary tract infection in men with symptomatic benign prostatic hyperplasia at a tertiary hospital in Nigeria","authors":"P. Ngwu, IE Ihedoro, EI Kalu","doi":"10.17352/jbm.000032","DOIUrl":null,"url":null,"abstract":"Introduction/Background: Benign Prostatic Hyperplasia (BPH) is characterized by narrowing of the prostatic urethra with resultant difficulty in passing urine, stasis, and a predisposition to urinary tract infection. The objective of this study is to identify the prevalence of urinary tract infections, common organisms isolated, their antimicrobial sensitivity pattern, and the relationship of co-morbidities with urinary tract infection in this population. Materials and methods: All patients who presented to our urology team with bladder outlet obstruction secondary to benign prostatic hyperplasia between January 2020 and January 2021 were included. Information on age, occupation, co-morbid conditions, urine microscopy, culture, and sensitivity patterns were obtained and analyzed using SPSS version 25. Midstream urine samples were collected from 172 BPH patients. Microscopy, culture, and antibiotic susceptibility tests were carried out. Results: From our study, the prevalence of bacteriuria was 67.9% with the 65-74 and 45-54 age groups having the highest and the least prevalence of bacteriuria (88.9% and 33.3% respectively). The most common organisms cultured from their urine were Pseudomonas (17.9%), E. coli (14.3%), Coliforms (10.7%), and Klebsiella (10.7%). Sensitivity patterns of these microorganisms revealed the highest sensitivity to the fluoroquinolones (25.9%) followed by Nitrofurantoin (14.8%) and Ceftriaxone and Cefoxitin (7.4%). The least sensitivity was to Augmentin and Gentamycin. Conclusion: Bacteriuria is common in patients with BPH. Pseudomonas spp was the commonest isolated organism in our study and most isolated organisms were susceptible to the fluoroquinolones.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Yale Journal of Biology and Medicine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.17352/jbm.000032","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction/Background: Benign Prostatic Hyperplasia (BPH) is characterized by narrowing of the prostatic urethra with resultant difficulty in passing urine, stasis, and a predisposition to urinary tract infection. The objective of this study is to identify the prevalence of urinary tract infections, common organisms isolated, their antimicrobial sensitivity pattern, and the relationship of co-morbidities with urinary tract infection in this population. Materials and methods: All patients who presented to our urology team with bladder outlet obstruction secondary to benign prostatic hyperplasia between January 2020 and January 2021 were included. Information on age, occupation, co-morbid conditions, urine microscopy, culture, and sensitivity patterns were obtained and analyzed using SPSS version 25. Midstream urine samples were collected from 172 BPH patients. Microscopy, culture, and antibiotic susceptibility tests were carried out. Results: From our study, the prevalence of bacteriuria was 67.9% with the 65-74 and 45-54 age groups having the highest and the least prevalence of bacteriuria (88.9% and 33.3% respectively). The most common organisms cultured from their urine were Pseudomonas (17.9%), E. coli (14.3%), Coliforms (10.7%), and Klebsiella (10.7%). Sensitivity patterns of these microorganisms revealed the highest sensitivity to the fluoroquinolones (25.9%) followed by Nitrofurantoin (14.8%) and Ceftriaxone and Cefoxitin (7.4%). The least sensitivity was to Augmentin and Gentamycin. Conclusion: Bacteriuria is common in patients with BPH. Pseudomonas spp was the commonest isolated organism in our study and most isolated organisms were susceptible to the fluoroquinolones.
期刊介绍:
The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.