Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels

Q4 Medicine

Russian Journal of Clinical Ophthalmology Pub Date : 2022-01-01 DOI:10.32364/2311-7729-2022-22-2-99-102

V.R. Abdulina, I. Stepanova

{"title":"Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels","authors":"V.R. Abdulina, I. Stepanova","doi":"10.32364/2311-7729-2022-22-2-99-102","DOIUrl":null,"url":null,"abstract":"Aim: to assess correlations between ocular ultrasound (US) biometry and optical coherence tomography (OCT) and hemoglobin A1c (HbA1c) in children with type 1 diabetes (T1D). Patients and Methods: 79 children were enrolled. The control group included 52 age-matched healthy children. Axial length (AL, mm) and lens thickness (LT, mm) were measured by US. Central corneal thickness (CCT) and central macular thickness (CMT) were measured by OCT (Cirrus 2000, Carl Zeiss Meditec, Germany). Correlation analysis to assess the relationship between HbA1c, US, and OCT was performed. Results: 55.7% of the participants were boys (n=44) and 44.3% were girls (n=35). Children were assigned into six groups depending on HbA1c levels. Group 1 (HbA1c <6.0%) included 8 children, group 2 (HbA1c 6.1–7.0%) 29 children, group 3 (HbA1c 7.1–8.0%) 21 children, group 4 (HbA1c 8.1–9.0%) 8 children, group 5 (HbA1c 9.1–10%) 5 children, and group 6 (HbA1c >10%) 8 children. The mean AL was 22.7±1.1 mm. The greatest AL was reported in groups 2 and 4, while the least AL was reported in groups 3 and 6. The greatest LT was reported in groups 4 and 6. In group 1, LT was similar to those in the control group. In all groups but group 2, CCT was greater than in controls. CMT demonstrated a negative correlation with HbA1c levels in the study groups. CMT was the greatest in children with T1D of 5 years’ durati Conclusion: in children with T1D, US and OCT findings correlate with HbA1c levels and T1D duration. Ocular biometry, CCT, and CMT measurements are useful tests illustrating the level of compensation of systemic disease. Dynamic assessment of these parameters will help develop indicators of diabetic retinopathy in children with T1D. Keywords: diabetes, ultrasound, optical coherence tomography, glycated hemoglobin. For citation: Abdulina V.R., Stepanova I.S. Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels. Russian Journal of Clinical Ophthalmology. 2022;22(2):99–102 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-99-102.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"8 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Clinical Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32364/2311-7729-2022-22-2-99-102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: to assess correlations between ocular ultrasound (US) biometry and optical coherence tomography (OCT) and hemoglobin A1c (HbA1c) in children with type 1 diabetes (T1D). Patients and Methods: 79 children were enrolled. The control group included 52 age-matched healthy children. Axial length (AL, mm) and lens thickness (LT, mm) were measured by US. Central corneal thickness (CCT) and central macular thickness (CMT) were measured by OCT (Cirrus 2000, Carl Zeiss Meditec, Germany). Correlation analysis to assess the relationship between HbA1c, US, and OCT was performed. Results: 55.7% of the participants were boys (n=44) and 44.3% were girls (n=35). Children were assigned into six groups depending on HbA1c levels. Group 1 (HbA1c <6.0%) included 8 children, group 2 (HbA1c 6.1–7.0%) 29 children, group 3 (HbA1c 7.1–8.0%) 21 children, group 4 (HbA1c 8.1–9.0%) 8 children, group 5 (HbA1c 9.1–10%) 5 children, and group 6 (HbA1c >10%) 8 children. The mean AL was 22.7±1.1 mm. The greatest AL was reported in groups 2 and 4, while the least AL was reported in groups 3 and 6. The greatest LT was reported in groups 4 and 6. In group 1, LT was similar to those in the control group. In all groups but group 2, CCT was greater than in controls. CMT demonstrated a negative correlation with HbA1c levels in the study groups. CMT was the greatest in children with T1D of 5 years’ durati Conclusion: in children with T1D, US and OCT findings correlate with HbA1c levels and T1D duration. Ocular biometry, CCT, and CMT measurements are useful tests illustrating the level of compensation of systemic disease. Dynamic assessment of these parameters will help develop indicators of diabetic retinopathy in children with T1D. Keywords: diabetes, ultrasound, optical coherence tomography, glycated hemoglobin. For citation: Abdulina V.R., Stepanova I.S. Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels. Russian Journal of Clinical Ophthalmology. 2022;22(2):99–102 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-99-102.

查看原文本刊更多论文

1型糖尿病儿童的功能测试及其与血红蛋白A1c水平的相关性

目的:探讨眼超声(US)生物测量和光学相干断层扫描(OCT)与1型糖尿病(T1D)患儿血红蛋白A1c (HbA1c)的相关性。患者和方法:纳入79名儿童。对照组包括52名年龄匹配的健康儿童。用超声测量轴向长度(AL, mm)和透镜厚度(LT, mm)。采用OCT测量角膜中央厚度(CCT)和黄斑中央厚度(CMT) (Cirrus 2000, Carl Zeiss Meditec，德国)。进行相关分析以评估HbA1c、US和OCT之间的关系。结果:男孩占55.7% (n=44)，女孩占44.3% (n=35)。根据HbA1c水平将儿童分为六组。1组(HbA1c 10%) 8例。平均AL为22.7±1.1 mm。第2、4组AL最大，第3、6组AL最小。第4组和第6组的LT最大。第1组的LT与对照组相似。除第2组外，其余各组CCT均高于对照组。在研究组中，CMT与HbA1c水平呈负相关。结论:在T1D儿童中，US和OCT结果与HbA1c水平和T1D病程相关。眼部生物测量、CCT和CMT测量是说明全身性疾病代偿水平的有用测试。动态评估这些参数将有助于制定T1D儿童糖尿病视网膜病变的指标。关键词:糖尿病，超声，光学相干断层扫描，糖化血红蛋白。引用本文:Abdulina V.R, Stepanova I.S. 1型糖尿病儿童的功能测试及其与血红蛋白A1c水平的相关性。俄罗斯临床眼科学杂志，2022;22(2):99-102。DOI: 10.32364 / 2311-7729-2022-22-2-99-102。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊